Phenotypes associated with this allele

• Allele Symbol: Sik1^tm1.2Berd
• Allele Name: targeted mutation 1.2, Rebecca Berdeaux
• Allele ID: MGI:5648836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sik1^tm1.2Berd/Sik1^tm1.2Berd	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	MGI:5805516

Genotype
MGI:5805516

hm1

• Allelic Composition: Sik1^tm1.2Berd/Sik1^tm1.2Berd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:236223 )

• fewer than expected mice are produced with lethality more pronounced in male mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236223 )

N • mice fed standard chow exhibit normal glucose tolerance, basal glucose production, and levels of plasma insulin, cholesterol, glycogen and triglycerides

N • mice fed a high-fat diet exhibit normal glucose tolerance

abnormal glucose homeostasis ( J:236223 )

• mice fed a high-fat diet exhibit reduced total glucose excursion compared with wild-type mice

decreased circulating glucose level ( J:236223 )

• slightly lower in the ad libitum fed state

• however, glucose level is normal in fasted mice

increased circulating insulin level ( J:236223 )

• in mice fed a high-fat diet

• however, mice fed chow exhibit normal insulin levels

increased insulin sensitivity ( J:236223 )

• when fed a high-fat diet

• however, mice fed chow exhibit normal insulin sensitivity

growth/size/body

decreased body weight ( J:236223 )

• defective anabolic growth whether fed chow or a high-fat diet