Phenotypes associated with this allele

• Allele Symbol: Spon1^tm1Gdpa
• Allele Name: targeted mutation 1, Glyn D Palmer
• Allele ID: MGI:5648858
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spon1^tm1Gdpa/Spon1^tm1Gdpa	Not Specified	MGI:5648860

Genotype
MGI:5648860

hm1

• Allelic Composition: Spon1^tm1Gdpa/Spon1^tm1Gdpa
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spon1^tm1Gdpa/Spon1^tm1Gdpa mice exhibit post-natal accumulation of bone

skeleton

abnormal femur morphology ( J:214251 )

• the endocortical bone perimeter appears distinctly irregular at 6 and 12 months of age

increased femur compact bone thickness ( J:214251 )

• at 6 but not at 12 months of age

increased trabecular bone volume ( J:214251 )

• at 3 and 6 months of age in the femurs and tibia

• phenotype is more pronounced at 6 months of age with an approximately 60% increase in bone volume

decreased bone trabecular spacing ( J:214251 )

• at 6 and 12 months of age

increased trabecular bone mass ( J:214251 )

• increase in femur and tibia trabecular number at 6 months of age but no change in trabecular thickness or total mineral density

abnormal bone remodeling ( J:214251 )

• expression analysis indicates increased levels of bone synthesis and resorption in femurs

increased bone resorption ( J:214251 )

abnormal chondrocyte physiology ( J:214251 )

• levels of secreted, total and active TGFB in isolated rib chondrocyte cell cultures are reduced compared to wild-type controls

homeostasis/metabolism

decreased transforming growth factor beta level ( J:214251 )

• serum levels of total TGFB1 are about 50% lower than in wild-type controls

limbs/digits/tail

abnormal femur morphology ( J:214251 )

• the endocortical bone perimeter appears distinctly irregular at 6 and 12 months of age

increased femur compact bone thickness ( J:214251 )

• at 6 but not at 12 months of age