Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-GCaMP5)Ryba}
• Allele Name: targeted mutation 1, Nicholas JP Ryba
• Allele ID: MGI:5649028
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-GCaMP5)Ryba/Gt(ROSA)26Sor^+ Hnrnpu^tm1.1Tman/Hnrnpu^tm1.1Tman Tg(Ckmm-cre)5Khn/0	involves: 129S4/SvJaeSor * FVB	MGI:5829563

Genotype
MGI:5829563

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-GCaMP5)Ryba}/Gt(ROSA)26Sor⁺; Hnrnpu^tm1.1Tman/Hnrnpu^tm1.1Tman; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S4/SvJaeSor * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:223139 )

• amplitude of heart contraction is significantly reduced relative to that in control hearts

• analysis of calcium cycling and heart contraction revealed impaired calcium handling

• hearts reach the maximal calcium level slightly slower than control hearts

• rate of post-contraction calcium decrease is significantly slower than that in controls hearts

• calcium decays almost linearly from the peak signal, in contrast to a two-phase (a rapid drop within the first 20 ms followed by a slower decrease for about 200 ms) reduction in control hearts

muscle

decreased cardiac muscle contractility ( J:223139 )

• amplitude of heart contraction is significantly reduced relative to that in control hearts

• analysis of calcium cycling and heart contraction revealed impaired calcium handling

• hearts reach the maximal calcium level slightly slower than control hearts

• rate of post-contraction calcium decrease is significantly slower than that in controls hearts

• calcium decays almost linearly from the peak signal, in contrast to a two-phase (a rapid drop within the first 20 ms followed by a slower decrease for about 200 ms) reduction in control hearts