Analysis Tools
neoplasm
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• mice develop a tumor within the skull between 3 and 6 months of age; tumors are found primarily in the brain parenchyma, but also in the choroid plexus and orbit
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• tumors show characteristic nests of polygonal cells with an open chromatin pattern, surrounded by neatly arcading capillary and larger vascular channels, resembling alveolar soft part sarcoma
• tumors often arise in or near the leptomeninges, along sulci
• some tumors show aggressive invasive growth, with extensions of tumor cells into the cerebellum, cerebrum, and the vessels of the choroid plexus
• mice do not develop tumors in the skeletal muscle
• tumors form in the areas highest in lactate, the cranial vault, express high levels of lactate importers, have abundant mitochondria, metabolize lactate as a metabolic substrate, and respond to exogenous lactate administration with increased cell proliferation and angiogenesis
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craniofacial
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• mice often exhibit enlargement of the occipital bone from the inner soft tissue expansion
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skeleton
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• mice often exhibit enlargement of the occipital bone from the inner soft tissue expansion
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| alveolar soft part sarcoma | DOID:4239 |
OMIM:606243 |
J:217462 | |
