Phenotypes associated with this allele

• Allele Symbol: Sorcs2^tm1Anyk
• Allele Name: targeted mutation 1, Anders Nykjaer
• Allele ID: MGI:5649357
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sorcs2^tm1Anyk/Sorcs2^tm1Anyk	B6.129-Sorcs2^tm1Anyk	MGI:5649360

Genotype
MGI:5649360

hm1

• Allelic Composition: Sorcs2^tm1Anyk/Sorcs2^tm1Anyk
• Genetic Background: B6.129-Sorcs2^tm1Anyk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:214739 )

N • no histological abnormalities are detected in the central nervous system

abnormal cerebral cortex morphology ( J:214739 )

• the infralimbic area of the frontal cortex is strikingly hyperinnervated by TH fibers

abnormal cerebellar granule cell morphology ( J:214739 )

• cultured cerebellar granule neurons grow markedly longer neurites

abnormal innervation ( J:214739 )

• the infralimbic area of the frontal cortex is strikingly hyperinnervated by TH fibers

abnormal neurite morphology ( J:214739 )

• cultured cerebellar granule neurons grow markedly longer neurites

abnormal neuron physiology ( J:214739 )

• cultured cerebellar granule neurons fail to show robust growth cone collapse in response to ProBDNF

behavior/neurological

abnormal behavioral response to addictive substance ( J:214739 )

• amphetamine induces reduced activity in an open field unlike in wild-type controls where activity is increased

increased locomotor activity ( J:214739 )

• increased activity in an open field test

homeostasis/metabolism

decreased dopamine level ( J:214739 )

• in the frontal cortex

• dopamine metabolism is decreased

decreased susceptibility to injury ( J:214739 )

• decrease in the induction of Schwann cell apoptosis following sciatic nerve injury compared to wild-type controls