Analysis Tools
homeostasis/metabolism
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• high-fat diet fed mice exhibit reduced fasted and fed serum-free fatty acids
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• mice fed a high-fat diet exhibit a minor increase in energy expenditure independent of any altered activity or respiratory quotient
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• mice fed a high-fat diet exhibit increased glucose clearance after 16 weeks on the high-fat diet
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• mice fed a high-fat diet exhibit increased insulin sensitivity after 16 weeks on the high-fat diet
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• mice are resistance to high-fat diet induced metabolic disease
• however, mice fed a chow diet develop normally, exhibit normal white blood cell counts, and appear healthy, with no alterations in body weight, food intake, glucose tolerance, insulin sensitivity, or plasma-free fatty acid levels
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growth/size/body
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• mice fed a high-fat diet exhibit a slightly reduced body weight gain compared to controls, despite similar food intake levels, although mice do become obese
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adipose tissue
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• adipocyte size is reduced in epididymal fat from high-fat diet fed mice compared to controls on the same diet
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cellular
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• naive bone marrow derived macrophages from high-fat diet fed mice show elevated basal respiration and spare respiratory capacity
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• naive bone marrow derived macrophages from high-fat diet fed mice show elevated basal and spare respiratory capacity and ATP-turnover
• increase in oxygen consumption rate of bone marrow derived macrophages from high-fat diet fed mice
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• bone marrow derived macrophages from high-fat diet fed mice exhibit an increase in intracellular hydrogen peroxide and an increase of cytosolic reactive oxygen species
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immune system
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• IL-1 beta secretion by bone marrow derived macrophages from high-fat diet fed mice is reduced
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• IL-6 secretion by bone marrow derived macrophages from high-fat diet fed mice is reduced
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• TNF-alpha secretion by bone marrow derived macrophages from high-fat diet fed mice is reduced
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• epididymal fat from high-fat diet fed mice shows improvements in metaflammation, with near absence of crown-like structures, reduced adipocyte size, and a reduction in macrophage infiltration
• adipose tissue from high-fat diet fed mice shows a 2-fold reduction in proinflammatory CD11c+ and CCR2+ macrophage infiltrates and an increase in numbers of protective M2-like MGL+ macrophages
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liver/biliary system
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• mice fed a high-fat diet exhibit attenuated liver steatosis compared to controls
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