All Phenotypes Nlgn3<tm4.1Sud> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlgn3^tm4.1Sud
targeted mutation 4.1, Thomas C Sudhof
MGI:5649372

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nlgn3^tm4.1Sud/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5660867
cn2	Nlgn3^tm4.1Sud/Y Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5660863
cn3	Nlgn3^tm4.1Sud/Y Tg(Drd1-cre)EY262Gsat/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL	MGI:5660864
cn4	Nlgn1^tm1.1Sud/Nlgn1^tm1.1Sud Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:5754963
cn5	Nlgn1^tm1.1Sud/Nlgn1^tm1.1Sud Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:5754948
cn6	Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:5754960
cn7	Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac	MGI:5754962
cn8	Nlgn3^tm4.1Sud/Y Tg(Adora2a-cre)2MDkde/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5660865
cn9	Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5660862
cn10	Nlgn3^tm4.1Sud/Y Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5660861

Allelic Composition	Nlgn3^tm4.1Sud/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced learning ( J:214636 )

• mice injected with Ad-cre in the nucleus accumbens exhibit enhanced learning on the accelerating rotarod

• however, mice injected with Ad-cre in the dorsal striatum show normal performance on the rotarod

hyperactivity ( J:214636 )

• mice injected with Ad-cre in the nucleus accumbens exhibit increased open-field activity

• however, mice injected with Ad-cre in the dorsal striatum show normal performance in the open-field

Allelic Composition	Nlgn3^tm4.1Sud/Y Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:214636 )

• mice exhibit decreased activity in the open field

• however, performance on the rotarod is normal

Allelic Composition	Nlgn3^tm4.1Sud/Y Tg(Drd1-cre)EY262Gsat/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced learning ( J:214636 )

• mice exhibit increased learning rate on the accelerating rotarod

hyperactivity ( J:214636 )

• mice exhibit increased open-field activity

Allelic Composition	Nlgn1^tm1.1Sud/Nlgn1^tm1.1Sud Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1^tm1.1Sud mutation (0 available); any Nlgn1 mutation (66 available)
Nlgn2^tm1.1Sud mutation (1 available); any Nlgn2 mutation (35 available)
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal synaptic bouton morphology ( J:227671 )

• bouton size is reduced

abnormal synapse morphology ( J:227671 )

• 50% decrease in density of climbing fiber synapse on distal Purkinje cell dendrites

• 15% decrease in density of climbing fiber synapse on proximal Purkinje cell dendrites

• inhibitory basket/stellate cell synapses are increased in size, but not number

• 25% decrease in size of climbing fiber synapse on distal and proximal Purkinje cell dendrites

• increase in puncta density as detected by GAD65

• parallel fiber synapse density is not altered

abnormal CNS synaptic transmission ( J:227671 )

• decreased frequency of delayed quantal release events, but not amplitude events

• impaired synaptic transmission at GABAergic synapses

decreased excitatory postsynaptic current amplitude ( J:227671 )

• 40% decrease in amplitude of climbing fiber EPSCs in juvenile and adult mice

• however, no change in kinetics or paired pulse ratio of climbing fiber EPSCs and no alterations in parallel-fiber EPSCs

abnormal inhibitory postsynaptic currents ( J:227671 )

• 80% decrease in IPSC amplitude in Purkinje cells, but no changes in kinetics or paired pulse ratio

abnormal miniature inhibitory postsynaptic currents ( J:227671 )

• 80% decrease in mIPSC frequency and amplitude (45%) in basket/stellate cell synapses

• decrease in decay, but not rise times of mIPSCs

decreased miniature inhibitory postsynaptic current amplitude ( J:227671 )

• 45% decrease in basket/stellate cell synapses

decreased miniature inhibitory postsynaptic current frequency ( J:227671 )

• 80% decrease in basket/stellate cell synapses

Allelic Composition	Nlgn1^tm1.1Sud/Nlgn1^tm1.1Sud Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1^tm1.1Sud mutation (0 available); any Nlgn1 mutation (66 available)
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:227671 )

N	• no change in parallel fiber synpatic transmission • no change in basket/stellate cell synapse-mediated mIPSCs

abnormal synapse morphology ( J:227671 )

• 5% loss of distal climbing-fiber synapse numbers

• 25% decrease in synapse size

decreased excitatory postsynaptic current amplitude ( J:227671 )

• modest decrease (10%) in climbing fiber synapse EPSC amplitude

• no change in paired pulse ratio is detected or synapse elimination

Allelic Composition	Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:227671 )

N	• no change in parallel fiber synpatic transmission • no change in basket/stellate cell synapse-mediated mIPSCs

decreased excitatory postsynaptic current amplitude ( J:227671 )

• small decrease in climbing fiber synapse EPSC amplitude

• no change in paired pulse ratio is detected

Allelic Composition	Nlgn2^tm1.1Sud/Nlgn2^tm1.1Sud Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn2^tm1.1Sud mutation (1 available); any Nlgn2 mutation (35 available)
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:227671 )

N	• no change in parallel fiber synpatic transmission

abnormal synapse morphology ( J:227671 )

• slight decrease in climbing-fiber synapse (vGluT2 staining) cluster density and size

decreased excitatory postsynaptic current amplitude ( J:227671 )

• decrease in climbing-fiber EPSC amplitude, but no change in quantal events

abnormal miniature inhibitory postsynaptic currents ( J:227671 )

• large decrease in frequency (90%) and amplitude (45%) of mIPScs

decreased miniature inhibitory postsynaptic current amplitude ( J:227671 )

• 45% decrease

decreased miniature inhibitory postsynaptic current frequency ( J:227671 )

• 90% decrease

Allelic Composition	Nlgn3^tm4.1Sud/Y Tg(Adora2a-cre)2MDkde/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Adora2a-cre)2MDkde mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:214636 )

N	• mice exhibit normal behavior in the open-field and on the rotarod

Allelic Composition	Nlgn3^tm4.1Sud/Y Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:214636 )

• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes

• however, mice exhibit normal performance on the rotarod

Allelic Composition	Nlgn3^tm4.1Sud/Y Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm4.1Sud mutation (0 available); any Nlgn3 mutation (36 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:214636 )

• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes

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