Phenotypes associated with this allele

• Allele Symbol: Septin7^tm1Mgl
• Allele Name: targeted mutation 1, Matthia Gaestel
• Allele ID: MGI:5660259
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Septin7^tm1Mgl/Septin7^tm1Mgl	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:5660274
cn2	Septin7^tm1Mgl/Septin7^tm1Mgl Tg(CD2-icre)4Kio/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5660277

Genotype
MGI:5660274

cn1

• Allelic Composition: Septin7^tm1Mgl/Septin7^tm1Mgl
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:223786 )

N • primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre exhibit normal apoptosis rates

increased cell mass ( J:223786 )

• in primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre

increased cell nucleus count ( J:223786 )

• in primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre

abnormal cell cycle ( J:223786 )

• primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre arrest at G2/M phase in the cell cycle unlike control mice

abnormal mitotic cytokinesis ( J:223786 )

• primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre exhibit impaired cytokinesis and stalled midbody abscission

• however, expression of stathmin rescues cytokinesis

decreased fibroblast proliferation ( J:223786 )

• in primary mouse embryonic fibroblasts transfected with either adeno- or retrovial vectors expressing cre

Genotype
MGI:5660277

cn2

• Allelic Composition: Septin7^tm1Mgl/Septin7^tm1Mgl; Tg(CD2-icre)4Kio/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/10 * CBA/Ca

immune system

immune system phenotype ( J:223786 )

N • mice exhibit normal numbers of peripheral blood cells

N • myeloid cells and lymphoid cells exhibit normal cytokinesis