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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Yap1tm2.1Dupa
targeted mutation 2.1, Duojia Pan
MGI:5660284
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Yap1tm2.1Dupa/Yap1tm2.1Dupa Not Specified MGI:5660286
cn2
 		Nf2tm2Gth/Nf2tm2Gth
Yap1tm2.1Dupa/Yap1tm2.1Dupa 		involves: 129P2/OlaHsd MGI:5660339


Genotype
MGI:5660286
hm1
Allelic
Composition		 Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yap1tm2.1Dupa mutation (0 available); any Yap1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:223215 )
• administration of the DNA alkylating agent, diethylnitrosamine (DEN), results in the development of massive hepatocellular carcinoma (HCC); in contrast to wild-type mice which do not develop visible carcinomas

neoplasm
increased incidence of tumors by chemical induction ( J:223215 )
• administration of the DNA alkylating agent, diethylnitrosamine (DEN), results in the development of massive hepatocellular carcinoma (HCC); in contrast to wild-type mice which do not develop visible carcinomas




Genotype
MGI:5660339
cn2
Allelic
Composition		 Nf2tm2Gth/Nf2tm2Gth
Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Yap1tm2.1Dupa mutation (0 available); any Yap1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver 2 months after adenovirus expressing Cre recombinase (Ad-Cre) injection (Ad-Cre) injection

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver 2 months after adenovirus expressing Cre recombinase (Ad-Cre) injection (Ad-Cre) injection
enlarged liver ( J:223215 )
• mice exhibit an enlarged liver 2 months after Ad-Cre injection
abnormal bile duct physiology ( J:223215 )
• mice develop massive bile duct hamarotomas 2 months after Ad-Cre injection as compared to contro

neoplasm
increased hamartoma incidence ( J:223215 )
• mice develop massive bile duct hamarotomas 2 months after Ad-Cre injection as compared to controls

growth/size/body
enlarged liver ( J:223215 )
• mice exhibit an enlarged liver 2 months after Ad-Cre injection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory