Phenotypes associated with this allele

• Allele Symbol: Trim9^tm1.1Slgu
• Allele Name: targeted mutation 1.1, Stephanie L Gupton
• Allele ID: MGI:5660333
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim9^tm1.1Slgu/Trim9^tm1.1Slgu	involves: 129S4/SvJae * BALB/cJ * C57BL/6	MGI:5660342
cx2	Tg(Thy1-EGFP)MJrs/0 Trim9^tm1.1Slgu/Trim9^tm1.1Slgu	involves: 129S4/SvJae * BALB/cJ * C57BL/6J * CBA	MGI:5660344

Genotype
MGI:5660342

hm1

• Allelic Composition: Trim9^tm1.1Slgu/Trim9^tm1.1Slgu
• Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:215804 )

• significant increase in axon branching in cortical neurons but no change in axon length

• treatment of neurons with botulinum toxin A reduces branching to wild-type levels

increased corpus callosum size ( J:215804 )

• increased thickness

abnormal neuron physiology ( J:215804 )

• increase in the exocytic frequency in the neurites

cellular

abnormal neuron differentiation ( J:215804 )

• significant increase in axon branching in cortical neurons but no change in axon length

• treatment of neurons with botulinum toxin A reduces branching to wild-type levels

Genotype
MGI:5660344

cx2

• Allelic Composition: Tg(Thy1-EGFP)MJrs/0; Trim9^tm1.1Slgu/Trim9^tm1.1Slgu
• Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * CBA

nervous system

abnormal neuron differentiation ( J:215804 )

• 4-fold increase in axon branching in the callosum

abnormal corpus callosum morphology ( J:215804 )

• 4-fold increase in axon branching in the callosum

increased corpus callosum size ( J:215804 )

• increased thickness

cellular

abnormal neuron differentiation ( J:215804 )

• 4-fold increase in axon branching in the callosum