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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igs2tm1(CAG-mt-Keima)Fink
targeted mutation 1, Toren Finkel
MGI:5660493
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igs2tm1(CAG-mt-Keima)Fink/Igs2tm1(CAG-mt-Keima)Fink either: FVBNCrl.129(Cg)-Igs2tm1(CAG-mt-Keima)Fink or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J * FVB/NCrl) MGI:5660611
cn2
 		Kansl1em1Cya/Kansl1em1Cya
Tg(CAG-cre/Esr1*)5Amc/0
Igs2tm1(CAG-mt-Keima)Fink/Igs2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N MGI:7763627
cn3
 		Kansl1em1Cya/Kansl1+
Tg(CAG-cre/Esr1*)5Amc/0
Igs2tm1(CAG-mt-Keima)Fink/Igs2+ 		Not Specified MGI:7763629
cx4
 		Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Lamp2tm1Psa/Lamp2tm1Psa 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:6259616
cx5
 		Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Kansl1em1.1Cya/Kansl1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:7763626


Genotype
MGI:5660611
hm1
Allelic
Composition		 Igs2tm1(CAG-mt-Keima)Fink/Igs2tm1(CAG-mt-Keima)Fink
Genetic
Background		 either: FVBNCrl.129(Cg)-Igs2tm1(CAG-mt-Keima)Fink or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J * FVB/NCrl)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:270139 )
• mice are viable and fertile




Genotype
MGI:7763627
cn2
Allelic
Composition		 Kansl1em1Cya/Kansl1em1Cya
Tg(CAG-cre/Esr1*)5Amc/0
Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (72 available)
Kansl1em1Cya mutation (0 available); any Kansl1 mutation (146 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitophagy ( J:327464 )
• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro

homeostasis/metabolism
abnormal mitophagy ( J:327464 )
• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro




Genotype
MGI:7763629
cn3
Allelic
Composition		 Kansl1em1Cya/Kansl1+
Tg(CAG-cre/Esr1*)5Amc/0
Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (72 available)
Kansl1em1Cya mutation (0 available); any Kansl1 mutation (146 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitophagy ( J:327464 )
• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro
• infection of lentiviral Stx17 into tamoxifen-treated neurons leads to partial restoration of mitophagic activity

homeostasis/metabolism
abnormal mitophagy ( J:327464 )
• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro
• infection of lentiviral Stx17 into tamoxifen-treated neurons leads to partial restoration of mitophagic activity




Genotype
MGI:6259616
cx4
Allelic
Composition		 Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Lamp2tm1Psa/Lamp2tm1Psa
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (72 available)
Lamp2tm1Psa mutation (0 available); any Lamp2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber physiology ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

cellular
abnormal mitophagy ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

homeostasis/metabolism
abnormal mitophagy ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles




Genotype
MGI:7763626
cx5
Allelic
Composition		 Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Kansl1em1.1Cya/Kansl1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (72 available)
Kansl1em1.1Cya mutation (0 available); any Kansl1 mutation (146 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitophagy ( J:327464 )
• basal mitophagic levels of hippocampus and heart are reduced

homeostasis/metabolism
abnormal mitophagy ( J:327464 )
• basal mitophagic levels of hippocampus and heart are reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory