Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Jup*)1Ajm
• Allele Name: transgene insertion 1, Ali J Marian
• Allele ID: MGI:5660496
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Jup^tm1Ruiz/Jup^tm1Ruiz Tg(Myh6-Jup*)1Ajm/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5660498
cx2	Jup^tm1Ruiz/Jup^+ Tg(Myh6-Jup*)1Ajm/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5660499
tg3	Tg(Myh6-Jup*)1Ajm/0	involves: FVB/N	MGI:5660497

Genotype
MGI:5660498

cx1

• Allelic Composition: Jup^tm1Ruiz/Jup^tm1Ruiz; Tg(Myh6-Jup*)1Ajm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:192719 )

• no viable pups are observed, indicating prenatal lethality

Genotype
MGI:5660499

cx2

• Allelic Composition: Jup^tm1Ruiz/Jup⁺; Tg(Myh6-Jup*)1Ajm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

cardiovascular system

abnormal cardiovascular system morphology ( J:192719 )

• mice exhibit similar cardiovascular phenotypes as single Tg(Myh6-Jup*)1Ajm transgenic mice

abnormal heart morphology ( J:192719 )

• increase in fibroadipocytes in the heart

thin interventricular septum ( J:192719 )

decreased heart left ventricle muscle contractility ( J:192719 )

• reduced left ventricular fractional shortening

abnormal heart echocardiography feature ( J:192719 )

• increase in left ventricular end diastolic diameter, left ventricular end systolic diameter, and left ventricular mass

adipose tissue

abnormal fat cell morphology ( J:192719 )

• increase in fibroadipocytes in the heart

muscle

decreased heart left ventricle muscle contractility ( J:192719 )

• reduced left ventricular fractional shortening

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arrhythmogenic right ventricular dysplasia 12		DOID:0110083	OMIM:611528	J:192719

Genotype
MGI:5660497

tg3

• Allelic Composition: Tg(Myh6-Jup*)1Ajm/0
• Genetic Background: involves: FVB/N

mortality/aging

premature death ( J:192719 )

• about 10%, 20%, and 60% of mice die at 6, 12, and 24 weeks of age, respectively

cardiovascular system

abnormal heart morphology ( J:192719 )

• increase in number of adipocytes in the heart, with predominant distribution in the epicardium and patchy distribution in the myocardium

abnormal heart weight ( J:192719 )

• the ventricular/body weight ratio is increased

enlarged heart ( J:192719 )

cardiac interstitial fibrosis ( J:192719 )

• interstitial fibrosis is increased about 2-fold

decreased heart left ventricle muscle contractility ( J:192719 )

• left ventricular fractional shortening is decreased

abnormal heart echocardiography feature ( J:192719 )

• left ventricular end diastolic diameter, end systolic diameter, left ventricular mass are increased

ventricular tachycardia ( J:192719 )

• electrocardiograms show evidence of supraventricular tachycardia in some mice

irregular heartbeat ( J:192719 )

• electrocardiograms show evidence of ventricular arrhythmias

atrioventricular block ( J:192719 )

• electrocardiograms show evidence of third-degree atrioventricular block and atrioventricular dissociation in some mice

adipose tissue

abnormal fat cell morphology ( J:192719 )

• increase in number of adipocytes in the heart, with predominant distribution in the epicardium and patchy adipocyte distribution in the myocardium

abnormal fat cell differentiation ( J:192719 )

• cardiac progenitor cells isolated from mutants exhibit enhanced adipogenesis

cellular

abnormal fat cell differentiation ( J:192719 )

• cardiac progenitor cells isolated from mutants exhibit enhanced adipogenesis

cardiac interstitial fibrosis ( J:192719 )

• interstitial fibrosis is increased about 2-fold

muscle

decreased heart left ventricle muscle contractility ( J:192719 )

• left ventricular fractional shortening is decreased

growth/size/body

enlarged heart ( J:192719 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arrhythmogenic right ventricular dysplasia 12		DOID:0110083	OMIM:611528	J:192719