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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcat1tm1.2Eaa
targeted mutation 1.2, Elitsa A Ananieva
MGI:5660825
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcat1tm1.2Eaa/Bcat1tm1.2Eaa involves: C57BL/6 MGI:5660829


Genotype
MGI:5660829
hm1
Allelic
Composition		 Bcat1tm1.2Eaa/Bcat1tm1.2Eaa
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcat1tm1.2Eaa mutation (0 available); any Bcat1 mutation (166 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell physiology ( J:216027 )
• decrease in Leu transamination
• increase in the concentration of branched chain amino acids in TCR stimulated cells compared to stimulated wild-type cells
• activated cells show an increase in glycolysis, glycolytic capacity, and glycolytic reserve

immune system
abnormal T cell physiology ( J:216027 )
• decrease in Leu transamination
• increase in the concentration of branched chain amino acids in TCR stimulated cells compared to stimulated wild-type cells
• activated cells show an increase in glycolysis, glycolytic capacity, and glycolytic reserve




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory