Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rack1tm1Sbif targeted mutation 1, Stefano Biffo MGI:5660834 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes die at gastrulation; mutant embryos are resorbed at E9.5
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• disorganized implanted blastocysts with vacuolar areas are observed at E6.5
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• absence of the early egg cylinder at E6.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• white belly spot in adult mice
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• hypopigmented paws in adult mice
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• hypopigmented tail tips in adult mice
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• transient decrease in body weight in females but not males at P11
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• transient decrease in head-anus length in females but not males at P11
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• transient growth delay in young females, not seen in males
• however, no gross alterations in embryonic development
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• reduced translation (protein synthesis) in response to stimulation with insulin or the PKC agonist PMA in heterozygous mutant MEFs relative to wild-type MEFs
• mildly increased 80S/polysome ratio in heterozygous mutant livers relative to wild-type livers
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• hypopigmented tail tips in adult mice
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• white belly spot in adult mice
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• hypopigmented paws in adult mice
|
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• hypopigmented tail tips in adult mice
|
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• reduced translation (protein synthesis) in response to stimulation with insulin or the PKC agonist PMA in heterozygous mutant MEFs relative to wild-type MEFs
• mildly increased 80S/polysome ratio in heterozygous mutant livers relative to wild-type livers
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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