Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rack1tm1Sbif targeted mutation 1, Stefano Biffo MGI:5660834 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygotes die at gastrulation; mutant embryos are resorbed at E9.5
|
|
• disorganized implanted blastocysts with vacuolar areas are observed at E6.5
|
|
• absence of the early egg cylinder at E6.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• white belly spot in adult mice
|
|
• hypopigmented paws in adult mice
|
|
• hypopigmented tail tips in adult mice
|
 |
• transient decrease in body weight in females but not males at P11
|
|
|
• transient decrease in head-anus length in females but not males at P11
|
|
|
• transient growth delay in young females, not seen in males
• however, no gross alterations in embryonic development
|
|
• reduced translation (protein synthesis) in response to stimulation with insulin or the PKC agonist PMA in heterozygous mutant MEFs relative to wild-type MEFs
• mildly increased 80S/polysome ratio in heterozygous mutant livers relative to wild-type livers
|
|
• hypopigmented tail tips in adult mice
|
|
• white belly spot in adult mice
|
|
• hypopigmented paws in adult mice
|
|
• hypopigmented tail tips in adult mice
|
|
• reduced translation (protein synthesis) in response to stimulation with insulin or the PKC agonist PMA in heterozygous mutant MEFs relative to wild-type MEFs
• mildly increased 80S/polysome ratio in heterozygous mutant livers relative to wild-type livers
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
