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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr2tm1.1Dnc
targeted mutation 1.1, Donald Cook
MGI:5660875
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr2tm1.1Dnc/Ccr2tm1.1Dnc Not Specified MGI:5661334


Genotype
MGI:5661334
hm1
Allelic
Composition		 Ccr2tm1.1Dnc/Ccr2tm1.1Dnc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1.1Dnc mutation (0 available); any Ccr2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal dendritic cell chemotaxis ( J:223508 )
• Ly-6Chi inflammatory dendritic cells (a CD11b subset) fail to migrate to lung following OVA/LPS instillation

hematopoietic system
abnormal dendritic cell chemotaxis ( J:223508 )
• Ly-6Chi inflammatory dendritic cells (a CD11b subset) fail to migrate to lung following OVA/LPS instillation
decreased CD11b-high dendritic cell number ( J:223508 )
• following OVA/LPS inhalation, mice exhibit reduced numbers of CD11bhi dendritic cells in the lungs as compared to wild-type
• reduction is due to a lack of Ly-6Chi inflammatory dendritic cells
increased dendritic cell number ( J:223508 )
• increased total number of lung dendritic cells under steady state conditions as compared to wild-type
increased CD11b-high dendritic cell number ( J:223508 )
• number of PKH+ CD11bhi dendritic cells is increased in mediastinal lymph nodes 24 hours after LPS treatment as compared to wild-type
• numbers of CD14med/lo> lung dendritic cells (a CD11b subset) are increased as compared to wild-type
• increased numbers of CD11bhi dendritic cells in the lung under steady state conditions as compared to wild-type

immune system
abnormal dendritic cell chemotaxis ( J:223508 )
• Ly-6Chi inflammatory dendritic cells (a CD11b subset) fail to migrate to lung following OVA/LPS instillation
decreased CD11b-high dendritic cell number ( J:223508 )
• following OVA/LPS inhalation, mice exhibit reduced numbers of CD11bhi dendritic cells in the lungs as compared to wild-type
• reduction is due to a lack of Ly-6Chi inflammatory dendritic cells
increased dendritic cell number ( J:223508 )
• increased total number of lung dendritic cells under steady state conditions as compared to wild-type
increased CD11b-high dendritic cell number ( J:223508 )
• number of PKH+ CD11bhi dendritic cells is increased in mediastinal lymph nodes 24 hours after LPS treatment as compared to wild-type
• numbers of CD14med/lo> lung dendritic cells (a CD11b subset) are increased as compared to wild-type
• increased numbers of CD11bhi dendritic cells in the lung under steady state conditions as compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory