Phenotypes associated with this allele

• Allele Symbol: Or8a1^{tm42(Mc4r)Mom}
• Allele Name: targeted mutation 42, Peter Mombaerts
• Allele ID: MGI:5661034
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Or8a1^tm42(Mc4r)Mom/Or8a1^tm42(Mc4r)Mom	B6;129P2-Or8a1^tm42(Mc4r)Mom/MomJ	MGI:6155741

Genotype
MGI:6155741

hm1

• Allelic Composition: Or8a1^{tm42(Mc4r)Mom}/Or8a1^{tm42(Mc4r)Mom}
• Genetic Background: B6;129P2-Or8a1^{tm42(Mc4r)Mom}/MomJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal olfactory sensory neuron morphology ( J:260975 )

• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive

decreased olfactory sensory neuron number ( J:260975 )

• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

growth/size/body

abnormal olfactory sensory neuron morphology ( J:260975 )

• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive

decreased olfactory sensory neuron number ( J:260975 )

• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

nervous system

abnormal olfactory sensory neuron morphology ( J:260975 )

• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive

decreased olfactory sensory neuron number ( J:260975 )

• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

respiratory system

abnormal olfactory sensory neuron morphology ( J:260975 )

• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive

decreased olfactory sensory neuron number ( J:260975 )

• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:260975 )

• although there is monoallelic expression of this substution allele and the expressed receptor responds to its specific agonist, Ro27-3225, but not OLFR151 agonists, 32% of the olfactory sensory neurons expressing this allele have an immature phenotype, being OMP negative and GAP43 positive

decreased olfactory sensory neuron number ( J:260975 )

• compared with GFP-tagged endogenous olfactory receptor 151 homozygotes, which show expression on 2928 +/- 152 olfactory sensory neurons, only 1013 +/- 92 olfactory sensory neurons express this substitution allele, and the glomeruli they form are much smaller than those formed by normal OLFR151-expressing olfactory sensory neurons