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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ankrd6tm1Pche
targeted mutation 1, Ping Chen
MGI:5661416
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ankrd6tm1Pche/Ankrd6tm1Pche involves: 129 MGI:5661424
cx2
 		Ankrd6tm1Pche/Ankrd6tm1Pche
Vangl2Lp/Vangl2+ 		involves: 129 * LPT/LeJ MGI:5661425


Genotype
MGI:5661424
hm1
Allelic
Composition		 Ankrd6tm1Pche/Ankrd6tm1Pche
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd6tm1Pche mutation (0 available); any Ankrd6 mutation (118 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:216288 )
N
• no hair cell defects are seen in the cochlea or vestibule
abnormal vestibular hair cell morphology ( J:216288 )
• uniform orientation of neighboring hair cells within the same side of the line of polarity reversal is disrupted in sporadic areas

nervous system
abnormal vestibular hair cell morphology ( J:216288 )
• uniform orientation of neighboring hair cells within the same side of the line of polarity reversal is disrupted in sporadic areas

behavior/neurological
behavior/neurological phenotype ( J:216288 )
N
• no behavioral abnormalities are seen




Genotype
MGI:5661425
cx2
Allelic
Composition		 Ankrd6tm1Pche/Ankrd6tm1Pche
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankrd6tm1Pche mutation (0 available); any Ankrd6 mutation (118 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal cochlear hair cell morphology ( J:216288 )
• patterning and polarity defects
abnormal cochlear outer hair cell morphology ( J:216288 )
• coordinated orientation of the outer-most row of hair cells is disrupted
• 29.2% of the 4th row of hair cells have an orientation deviation of 30 degrees or larger from the planar cell polarity axis compared to only 0.9% of hairs in wild-type controls

reproductive system
female infertility ( J:216288 )
• all females are sterile compared to less than 10% of mice heterozygous for Vangl2Lp alone

nervous system
abnormal cochlear hair cell morphology ( J:216288 )
• patterning and polarity defects
abnormal cochlear outer hair cell morphology ( J:216288 )
• coordinated orientation of the outer-most row of hair cells is disrupted
• 29.2% of the 4th row of hair cells have an orientation deviation of 30 degrees or larger from the planar cell polarity axis compared to only 0.9% of hairs in wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory