behavior/neurological
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• male mice exhibit normal exploratory behavior
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• female mice exhibit increased freezing for the first 6 minutes of the test and then a decline unlike Comttm2(COMT)Xzho homozygotes
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• female mice exhibit decreased cued fear recall compared with Comttm2(COMT)Xzho homozygotes
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• male and female mice exhibit reduced alternation compared with chance
• tolcapone treatment increases alteration unlike Comttm2(COMT)Xzho homozygotes
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• in male mice compared with male Comttm2(COMT)Xzho homozygotes
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• in female mice compared with female Comttm2(COMT)Xzho homozygotes
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nervous system
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• in male mice compared with male Comttm2(COMT)Xzho homozygotes
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• in female mice compared with female Comttm2(COMT)Xzho homozygotes
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