Phenotypes associated with this allele

• Allele Symbol: Comt^{tm1(COMT)Xzho}
• Allele Name: targeted mutation 1, Xianjin Zhou
• Allele ID: MGI:5661839
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Comt^tm1(COMT)Xzho/Comt^tm1(COMT)Xzho	involves: 129 * C57BL/6J	MGI:5661879

Genotype
MGI:5661879

hm1

• Allelic Composition: Comt^{tm1(COMT)Xzho}/Comt^{tm1(COMT)Xzho}
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:224284 )

♂N • male mice exhibit normal exploratory behavior

enhanced contextual conditioning behavior ( J:224284 )

♀ • female mice exhibit increased freezing for the first 6 minutes of the test and then a decline unlike Comt^{tm2(COMT)Xzho} homozygotes

impaired cued conditioning behavior ( J:224284 )

♀ • female mice exhibit decreased cued fear recall compared with Comt^{tm2(COMT)Xzho} homozygotes

abnormal spatial working memory ( J:224284 )

• male and female mice exhibit reduced alternation compared with chance

• tolcapone treatment increases alteration unlike Comt^{tm2(COMT)Xzho} homozygotes

increased startle reflex ( J:224284 )

♂ • in male mice compared with male Comt^{tm2(COMT)Xzho} homozygotes

decreased vertical activity ( J:224284 )

♀ • in female mice compared with female Comt^{tm2(COMT)Xzho} homozygotes

nervous system

decreased prepulse inhibition ( J:224284 )

♂ • in male mice compared with male Comt^{tm2(COMT)Xzho} homozygotes

increased prepulse inhibition ( J:224284 )

♀ • in female mice compared with female Comt^{tm2(COMT)Xzho} homozygotes