Phenotypes associated with this allele

• Allele Symbol: Comt^{tm2(COMT)Xzho}
• Allele Name: targeted mutation 1, Xianjin Zhou
• Allele ID: MGI:5661843
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Comt^tm2(COMT)Xzho/Comt^tm2(COMT)Xzho	involves: 129 * C57BL/6J	MGI:5661880

Genotype
MGI:5661880

hm1

• Allelic Composition: Comt^{tm2(COMT)Xzho}/Comt^{tm2(COMT)Xzho}
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:224284 )

N • male mice exhibit normal exploratory behavior and contextual freezing

N • female mice exhibit normal contextual freezing

impaired contextual conditioning behavior ( J:224284 )

♀ • female mice exhibit increased freezing compared with Comt^{tm1(COMT)Xzho} homozygotes

enhanced cued conditioning behavior ( J:224284 )

♀ • female mice exhibit increased cued fear recall in the initial two blocks of testing which then disappeared with further extinction training trials compared with Comt^{tm1(COMT)Xzho} homozygotes

abnormal spatial working memory ( J:224284 )

• male and female mice exhibit increased alternation compared with chance

abnormal fear-related response ( J:224284 )

♀ • during the extinction recall test, female mice exhibit higher cued fear in the first block but rapidly reduced freezing in subsequent block compared with Comt^{tm1(COMT)Xzho} homozygotes

decreased startle reflex ( J:224284 )

♂ • in male mice compared with male Comt^{tm1(COMT)Xzho} homozygotes

increased vertical activity ( J:224284 )

♀ • in female mice compared with female Comt^{tm1(COMT)Xzho} homozygotes

nervous system

decreased prepulse inhibition ( J:224284 )

♀ • in female mice compared with female Comt^{tm1(COMT)Xzho} homozygotes

increased prepulse inhibition ( J:224284 )

♂ • in male mice compared with male Comt^{tm1(COMT)Xzho} homozygotes