Phenotypes associated with this allele

• Allele Symbol: Ints10^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5661967
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ints10^tm1b(KOMP)Wtsi/Ints10^tm1b(KOMP)Wtsi	C57BL/6N-Ints10^tm1b(KOMP)Wtsi/J	MGI:6262702
ht2	Ints10^tm1b(KOMP)Wtsi/Ints10^+	C57BL/6N-Ints10^tm1b(KOMP)Wtsi/J	MGI:6262701

Genotype
MGI:6262702

hm1

• Allelic Composition: Ints10^{tm1b(KOMP)Wtsi}/Ints10^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Ints10^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0044_1_B02

Data Sources

IMPC Data for Ints10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:211773 )

♀

IMPC - JAX

embryo

abnormal embryo turning ( J:211773 )

IMPC - JAX

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

abnormal neural tube closure ( J:211773 )

IMPC - JAX

abnormal chorioallantoic fusion ( J:211773 )

IMPC - JAX

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - JAX

Genotype
MGI:6262701

ht2

• Allelic Composition: Ints10^{tm1b(KOMP)Wtsi}/Ints10⁺
• Genetic Background: C57BL/6N-Ints10^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0044_1_B02

Data Sources

IMPC Data for Ints10

behavior/neurological

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♀

IMPC - JAX

vision/eye

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

persistence of hyaloid vascular system ( J:211773 )

IMPC - JAX