Phenotypes associated with this allele

• Allele Symbol: Chrna7^{tm2.1(cre)Swr}
• Allele Name: targeted mutation 2.1, Scott W Rogers
• Allele ID: MGI:5662228
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor^+ Chrna7^tm2.1(cre)Swr/Chrna7^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5662242

Genotype
MGI:5662242

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺; Chrna7^{tm2.1(cre)Swr}/Chrna7⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:223063 )

• mice are stillborn

embryo

embryo phenotype ( J:223063 )

N • placenta organization is grossly normal

abnormal rostral-caudal axis patterning ( J:223063 )

• exaggerated curvature

• however, supplementation with choline improves caudal body axis size

delayed caudal neuropore closure ( J:223063 )

spina bifida ( J:223063 )

• visible as early as E11.5

• evident at E16.5 without full penetrance

• open spina bifida in 9 of 13 pups

• treatment with oral nicotine increases spina bifida incidence and severity

• however, supplementation with folic acid and choline reduces frequency of occurrence

craniofacial

abnormal craniofacial morphology ( J:223063 )

• rare and restricted to the mandible

macrodontia ( J:223063 )

• enlarged teeth at E16.5

short mandible ( J:223063 )

flat head ( J:223063 )

• in stillborn mice

growth/size/body

macrodontia ( J:223063 )

• enlarged teeth at E16.5

flat head ( J:223063 )

• in stillborn mice

enlarged pancreas ( J:223063 )

abnormal abdominal wall morphology ( J:223063 )

• with peritoneal membrane enclosing the extruded liver and intestine at E16.5

omphalocele ( J:223063 )

• evident at E16.5 without full penetrance

• protrusion of abdominal organs (liver and intestines) suggestive of an omphalocele

enlarged liver ( J:223063 )

• at E16.5

limbs/digits/tail

abnormal limb bone morphology ( J:223063 )

• abnormal proportioned limbs in stillborn mice

abnormal tail morphology ( J:223063 )

• tail defects are not improved by folic acid supplementation

• however, supplementation with choline improves tail bud defects

• reminiscent of Grhl3^ct

• reverted tail tip

nervous system

delayed caudal neuropore closure ( J:223063 )

spina bifida ( J:223063 )

• visible as early as E11.5

• evident at E16.5 without full penetrance

• open spina bifida in 9 of 13 pups

• treatment with oral nicotine increases spina bifida incidence and severity

• however, supplementation with folic acid and choline reduces frequency of occurrence

abnormal dorsal root ganglion morphology ( J:223063 )

• extruded dorsal root ganglia at E16.5

dorsal root ganglion hypoplasia ( J:223063 )

vision/eye

abnormal retina pigment epithelium morphology ( J:223063 )

• absence or disorganized at E16.5

behavior/neurological

hunched posture ( J:223063 )

• in stillborn mice

digestive/alimentary system

enlarged salivary gland ( J:223063 )

• at E16.5

endocrine/exocrine glands

enlarged salivary gland ( J:223063 )

• at E16.5

enlarged pancreas ( J:223063 )

hematopoietic system

anemia ( J:223063 )

• in some embryos

liver/biliary system

enlarged liver ( J:223063 )

• at E16.5

pigmentation

abnormal retina pigment epithelium morphology ( J:223063 )

• absence or disorganized at E16.5

skeleton

macrodontia ( J:223063 )

• enlarged teeth at E16.5

short mandible ( J:223063 )

abnormal limb bone morphology ( J:223063 )

• abnormal proportioned limbs in stillborn mice