Phenotypes associated with this allele

• Allele Symbol: Camk2a^tm1.1Yelg
• Allele Name: targeted mutation 1.1, Ype Elgersma
• Allele ID: MGI:5662417
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg Emx1^tm1.1(cre)Ito/0	B6J.Cg-Camk2a^tm1.1Yelg Emx1^tm1.1(cre)Ito	MGI:5795689
cn2	Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg Tg(CAG-cre/Esr1*)5Amc/0	B6J.Cg-Camk2a^tm1.1Yelg Tg(CAG-cre/Esr1*)5Amc	MGI:5795687
cn3	Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg Tg(Pcp2-cre)2Mpin/0	B6J.Cg-Camk2a^tm1.1Yelg Tg(Pcp2-cre)2Mpin	MGI:5795691

Genotype
MGI:5795689

cn1

• Allelic Composition: Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg; Emx1^{tm1.1(cre)Ito}/0
• Genetic Background: B6J.Cg-Camk2a^tm1.1Yelg Emx1^{tm1.1(cre)Ito}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:216169 )

• mice show severe contextual fear learning deficits relative to control littermates, as revealed by a marked reduction in elicited freezing behavior

impaired spatial learning ( J:216169 )

• in the hidden version of the Morris water maze, mice search equally in all four quadrants with no clear preference for the target quadrant during the probe trial, and show a significant reduction in their latency time to reach the hidden platform at day 3, but not at the initial or final (day 5) training days relative to control littermates

• however, no significant differences in thigmotaxis, swim speed, or path length are observed

Genotype
MGI:5795687

cn2

• Allelic Composition: Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: B6J.Cg-Camk2a^tm1.1Yelg Tg(CAG-cre/Esr1*)5Amc

behavior/neurological

impaired contextual conditioning behavior ( J:216169 )

• adult mice treated with tamoxifen show severe contextual fear learning deficits relative to control littermates, as revealed by a marked reduction in elicited freezing behavior

impaired spatial learning ( J:216169 )

• in the hidden version of the Morris water maze, adult mice treated with tamoxifen search equally in all four quadrants with no clear preference for the target quadrant during the probe trial, unlike control littermates

• however, no significant differences in latency times to reach the hidden platform, thigmotaxis, swim speed, or path length are observed

nervous system

impaired synaptic plasticity ( J:216169 )

• adult mice treated with tamoxifen exhibit impaired synaptic plasticity

reduced long-term potentiation ( J:216169 )

• adult mice treated with tamoxifen show impaired LTP induction at the CA3-CA1 synapse in the hippocampus in two independent stimulation protocols (100 Hz and theta-burst) relative to control littermates

• however, basal synaptic transmission and paired-pulse facilitation (PPF) are normal

Genotype
MGI:5795691

cn3

• Allelic Composition: Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg; Tg(Pcp2-cre)2Mpin/0
• Genetic Background: B6J.Cg-Camk2a^tm1.1Yelg Tg(Pcp2-cre)2Mpin

behavior/neurological

behavior/neurological phenotype ( J:216169 )

N • at 2-5 months of age, mice exhibit normal spatial learning in the hidden version of the Morris water maze with a clear preference for the platform quadrant during the probe trial and a similar reduction in latency times during training relative to control littermates

N • in addition, mice display intact contextual fear conditioning relative to control littermates