Phenotypes associated with this allele

• Allele Symbol: Ccdc80^tm1.1Ftk
• Allele Name: targeted mutation 1.1, Frank T Kolligs
• Allele ID: MGI:5662451
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc80^tm1.1Ftk/Ccdc80^tm1.1Ftk	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N	MGI:5693794
cx2	Apc^Min/Apc^+ Ccdc80^tm1.1Ftk/Ccdc80^tm1.1Ftk	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N	MGI:5693797

Genotype
MGI:5693794

hm1

• Allelic Composition: Ccdc80^tm1.1Ftk/Ccdc80^tm1.1Ftk
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:216704 )

• 1 of 13 mice develop a single hepatocellular carcinoma

liver/biliary system

increased hepatocellular carcinoma incidence ( J:216704 )

• 1 of 13 mice develop a single hepatocellular carcinoma

digestive/alimentary system

digestive/alimentary phenotype ( J:216704 )

N • mice do not develop intestinal tumors and do not exhibit small intestine or colon abnormalities

mortality/aging

mortality/aging ( J:216704 )

N • mice are viable and fertile and exhibit normal litter size and mortality

Genotype
MGI:5693797

cx2

• Allelic Composition: Apc^Min/Apc⁺; Ccdc80^tm1.1Ftk/Ccdc80^tm1.1Ftk
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * C57BL/6J * C57BL/6N

mortality/aging

premature death ( J:216704 )

• median survival is 94 days compared to 142 days in control Apc^Min heterozygotes

neoplasm

increased gastrointestinal tumor incidence ( J:216704 )

• mice develop tumors in the small intestine with no difference in number, distribution, size and histology from tumors in single Apc^Min heterozygotes

increased colon tumor incidence ( J:216704 )

• mean number of colonic tumors is 11.9 compared to 3.1 in control Apc^Min heterozygotes and mice show an increase in mean tumor multiplicity in both the proximal and distal colon

• by 10 weeks of age, mice show more tumors in the colon than in single Apc^Min heterozygotes, with 29% of tumors being adenocarcinoma

• no metastases to lymph nodes, liver or lungs are seen

increased colon adenoma incidence ( J:216704 )

• 65% of colon tumors are adenomas

increased colon adenocarcinoma incidence ( J:216704 )

• 35% of colon tumors are adenocarcinomas

• 97% of carcinomas are located in the distal colon

digestive/alimentary system

intestine polyps ( J:216704 )

• vast majority of polyps localize to the small intestine

increased gastrointestinal tumor incidence ( J:216704 )

• mice develop tumors in the small intestine with no difference in number, distribution, size and histology from tumors in single Apc^Min heterozygotes

increased colon tumor incidence ( J:216704 )

• mean number of colonic tumors is 11.9 compared to 3.1 in control Apc^Min heterozygotes and mice show an increase in mean tumor multiplicity in both the proximal and distal colon

• by 10 weeks of age, mice show more tumors in the colon than in single Apc^Min heterozygotes, with 29% of tumors being adenocarcinoma

• no metastases to lymph nodes, liver or lungs are seen

increased colon adenoma incidence ( J:216704 )

• 65% of colon tumors are adenomas

increased colon adenocarcinoma incidence ( J:216704 )

• 35% of colon tumors are adenocarcinomas

• 97% of carcinomas are located in the distal colon

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:216704