Phenotypes associated with this allele

• Allele Symbol: Sgms1^tm1Jia
• Allele Name: targeted mutation 1, Xian-Cheng Jiang
• Allele ID: MGI:5662506
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgms1^tm1Jia/Sgms1^tm1Jia	involves: C57BL/6	MGI:5693567

Genotype
MGI:5693567

hm1

• Allelic Composition: Sgms1^tm1Jia/Sgms1^tm1Jia
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:201497 )

N • no changes in plasma lipid levels (total cholesterol, phospholipids, triglycerides)

N • plasma ceramide levels similar to controls

abnormal sphingomyelin level ( J:201497 )

• plasma sphingomyelin reduced to 52% of control level

• liver sphingomyelin levels reduced to 36% of control levels

• 65% less sphingomyelin in macrophage cell membranes

abnormal ceramide level ( J:201497 )

• liver ceremide levels decreased to 26% of controls

• liver glucosylceramide levels increased 12X

• liver GM3 levels increased 7X

• 8.5 fold more glucosylceramide and 6.2 fold more GM3 in macrophage cell membranes

• plasma glucosylceramide levels increased 7 fold

• plasma GM3 levels increased 6 fold

abnormal cytokine level ( J:201497 )

decreased circulating interleukin-6 level ( J:201497 )

• significantly decreased plasma levels of IL-6 after LPS stimulation

decreased circulating tumor necrosis factor level ( J:201497 )

• significantly decreased plasma levels of TNF alpha after LPS stimulation

immune system

abnormal cytokine level ( J:201497 )

decreased circulating interleukin-6 level ( J:201497 )

• significantly decreased plasma levels of IL-6 after LPS stimulation

decreased circulating tumor necrosis factor level ( J:201497 )

• significantly decreased plasma levels of TNF alpha after LPS stimulation

abnormal cytokine secretion ( J:201497 )

decreased interleukin-6 secretion ( J:201497 )

• attenuated LPS mediated IL-6 secretion from macrophage

decreased tumor necrosis factor secretion ( J:201497 )

• attenuated LPS mediated TNF alpha secretion from macrophage