Phenotypes associated with this allele

• Allele Symbol: Mtdh^tm1.2Dsar
• Allele Name: targeted mutation 1.2, Devanand Sarkar
• Allele ID: MGI:5662534
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtdh^tm1.2Dsar/Mtdh^tm1.2Dsar	either: B6.129(FVB)-Mtdh^tm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)	MGI:5810065
ht2	Mtdh^tm1.2Dsar/Mtdh^+	either: B6.129(FVB)-Mtdh^tm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)	MGI:5810064

Genotype
MGI:5810065

hm1

• Allelic Composition: Mtdh^tm1.2Dsar/Mtdh^tm1.2Dsar
• Genetic Background: either: B6.129(FVB)-Mtdh^tm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:216688 )

• mice are resistant to the carcinogen N-nitrosodiethylamine (DEN) or DEN plus phenobarbital (PB) induced hepatocellular carcinoma (HCC)

• following treatment, mice develop either no tumors or very small tumors

• DEN+PB treatment produces some level of dysplasia, but not HCC

decreased organ/body region tumor incidence ( J:216688 )

• spontaneous lung, heart and liver tumors are not observed in 16 month old mice

• macrophage infiltration of the liver is not observed in aged (16 month old) mice

decreased cardiovascular system tumor incidence ( J:216688 )

• 16 month old mice do not develop spontaneous myxoma as compared to wild-type

decreased liver tumor incidence ( J:216688 )

• 16 month old mice do not develop spontaneous lymphoma and adenocarcinoma as compared to wild-type

decreased lung tumor incidence ( J:216688 )

• 16 month old mice do not develop spontaneous adenocarcinoma and carcinoid tumors as compared to wild-type

cellular

decreased macrophage proliferation ( J:216688 )

• macrophage infiltration of the liver is not observed in aged (16 month old) mice

hematopoietic system

decreased macrophage proliferation ( J:216688 )

• macrophage infiltration of the liver is not observed in aged (16 month old) mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:216688 )

• mice are resistant to the carcinogen N-nitrosodiethylamine (DEN) or DEN plus phenobarbital (PB) induced hepatocellular carcinoma (HCC)

• following treatment, mice develop either no tumors or very small tumors

• DEN+PB treatment produces some level of dysplasia, but not HCC

immune system

decreased macrophage proliferation ( J:216688 )

• macrophage infiltration of the liver is not observed in aged (16 month old) mice

decreased interleukin-1 beta secretion ( J:216688 )

• LPS-mediated IL1beta induction is blunted in comparison to wild-type

decreased interleukin-6 secretion ( J:216688 )

• LPS-mediated IL6 induction is blunted in comparison to wild-type

liver/biliary system

decreased liver tumor incidence ( J:216688 )

• 16 month old mice do not develop spontaneous lymphoma and adenocarcinoma as compared to wild-type

cardiovascular system

decreased cardiovascular system tumor incidence ( J:216688 )

• 16 month old mice do not develop spontaneous myxoma as compared to wild-type

reproductive system

decreased litter size ( J:216688 )

respiratory system

decreased lung tumor incidence ( J:216688 )

• 16 month old mice do not develop spontaneous adenocarcinoma and carcinoid tumors as compared to wild-type

Genotype
MGI:5810064

ht2

• Allelic Composition: Mtdh^tm1.2Dsar/Mtdh⁺
• Genetic Background: either: B6.129(FVB)-Mtdh^tm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)

reproductive system

decreased litter size ( J:216688 )

• small litter sizes (1-2 pups/litter)