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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Jak1tm1Kuw
targeted mutation 1, Kay-Uwe Wagner
MGI:5688302
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Jak1tm1Kuw/Jak1tm1Kuw involves: 129X1/SvJ * C57BL/6 MGI:5796276
cn2
 		Jak1tm1Kuw/Jak1tm1Kuw
Tg(Wap-cre)11738Mam/0 		involves: 129X1/SvJ * C57BL/6 * SJL MGI:5796283
cn3
 		Jak1tm1Kuw/Jak1tm1Kuw
Tg(MMTV-cre)1Mam/0 		involves: 129X1/SvJ * FVB MGI:5796282


Genotype
MGI:5796276
hm1
Allelic
Composition		 Jak1tm1Kuw/Jak1tm1Kuw
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak1tm1Kuw mutation (1 available); any Jak1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:235355 )
• mice develop normally until adulthood, are fertile, and do not exhibit phenotypic abnormalities




Genotype
MGI:5796283
cn2
Allelic
Composition		 Jak1tm1Kuw/Jak1tm1Kuw
Tg(Wap-cre)11738Mam/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak1tm1Kuw mutation (1 available); any Jak1 mutation (50 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal involution of the mammary gland ( J:235354 )
• delay in postlactational remodeling of the mammary gland

integument
abnormal involution of the mammary gland ( J:235354 )
• delay in postlactational remodeling of the mammary gland




Genotype
MGI:5796282
cn3
Allelic
Composition		 Jak1tm1Kuw/Jak1tm1Kuw
Tg(MMTV-cre)1Mam/0
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak1tm1Kuw mutation (1 available); any Jak1 mutation (50 available)
Tg(MMTV-cre)1Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal involution of the mammary gland ( J:235354 )
• females exhibit a delay in postlactational mammary gland remodeling starting at 3 days post weaning and these abnormalities are still evident after 5 days of involution
• however, females lactate normally, and show normal ductal elongation and branching morphogenesis, and mammary gland alveologenesis during pregnancy

integument
abnormal involution of the mammary gland ( J:235354 )
• females exhibit a delay in postlactational mammary gland remodeling starting at 3 days post weaning and these abnormalities are still evident after 5 days of involution
• however, females lactate normally, and show normal ductal elongation and branching morphogenesis, and mammary gland alveologenesis during pregnancy




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory