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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fancbem1Shnk
endonuclease-mediated mutation 1, Satoshi H Namekawa
MGI:5688399
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fancbem1Shnk/Fancbem1Shnk C57BL/6J-Fancbem1Shnk MGI:5688471


Genotype
MGI:5688471
hm1
Allelic
Composition		 Fancbem1Shnk/Fancbem1Shnk
Genetic
Background		 C57BL/6J-Fancbem1Shnk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancbem1Shnk mutation (0 available); any Fancb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogonia morphology ( J:224588 )
• defects in the maintenance of undifferentiated spermatogonia
decreased primordial germ cell number ( J:224588 )
• reduced primordial germ cells in male mice
• however, no primordial germ cells are detected outside of the gonadal ridge
increased male germ cell apoptosis ( J:224588 )
• increased apoptosis in testes, at the periphery of seminiferous tubules and in differentiated spermatids
increased Sertoli cell number ( J:224588 )
• enriched Sertoli cells
small seminiferous tubules ( J:224588 )
• at 4 and 10 weeks
small testis ( J:224588 )
• at 4 and 10 weeks

growth/size/body
decreased body size ( J:224588 )
postnatal growth retardation ( J:224588 )

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:224588 )
• increase in the number of persistent double strand breaks in male germ cells
• however, male germ cells exhibit normal meiotic recombination

cellular
abnormal spermatogonia morphology ( J:224588 )
• defects in the maintenance of undifferentiated spermatogonia
decreased primordial germ cell number ( J:224588 )
• reduced primordial germ cells in male mice
• however, no primordial germ cells are detected outside of the gonadal ridge
increased male germ cell apoptosis ( J:224588 )
• increased apoptosis in testes, at the periphery of seminiferous tubules and in differentiated spermatids
abnormal double-strand DNA break repair ( J:224588 )
• increase in the number of persistent double strand breaks in male germ cells
• however, male germ cells exhibit normal meiotic recombination

endocrine/exocrine glands
increased Sertoli cell number ( J:224588 )
• enriched Sertoli cells
small seminiferous tubules ( J:224588 )
• at 4 and 10 weeks
small testis ( J:224588 )
• at 4 and 10 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory