Phenotypes associated with this allele

• Allele Symbol: Mydgf^tm1Kcw
• Allele Name: targeted mutation 1, Kai C Wollert
• Allele ID: MGI:5688472
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mydgf^tm1Kcw/Mydgf^tm1Kcw	BALB/c-Mydgf^tm1Kcw	MGI:5688475

Genotype
MGI:5688475

hm1

• Allelic Composition: Mydgf^tm1Kcw/Mydgf^tm1Kcw
• Genetic Background: BALB/c-Mydgf^tm1Kcw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:216795 )

N • no abnormalities are detected in left ventricular (LV) mass, LV end-diastolic and end-systolic dimensions, LV systolic function (fractional area change), tail-cuff blood pressure or heart rate under baseline conditions

N • no abnormalities in developmental angiogenesis are detected

abnormal response to cardiac infarction ( J:216795 )

• impaired angiogenic response in the infarct zone

• no difference in angiogenesis is detected outside the infarct zone or in sham operated animals

• develop greater infarct scars, more severe LV remodeling and more pronounced systolic dysfunction compared to wild-type controls

• fewer proinflammatory Ly6C-high monocytes are detected in the infarct zone 1d after reperfusion

• bone marrow transplants from wild-type mice normalizes responses to infarction

increased myocardial infarct size ( J:216795 )

• following coronary artery ligation with an increase in apoptotic cells and a decrease in proliferating endothelial cells in the border zone after reperfusion

homeostasis/metabolism

abnormal response to cardiac infarction ( J:216795 )

• impaired angiogenic response in the infarct zone

• no difference in angiogenesis is detected outside the infarct zone or in sham operated animals

• develop greater infarct scars, more severe LV remodeling and more pronounced systolic dysfunction compared to wild-type controls

• fewer proinflammatory Ly6C-high monocytes are detected in the infarct zone 1d after reperfusion

• bone marrow transplants from wild-type mice normalizes responses to infarction

increased myocardial infarct size ( J:216795 )

• following coronary artery ligation with an increase in apoptotic cells and a decrease in proliferating endothelial cells in the border zone after reperfusion

immune system

decreased inflammatory response ( J:216795 )

• fewer proinflammatory Ly6C-high monocytes are detected in the infarct zone 1d after reperfusion