All Phenotypes Tg(SFTPC-Il18)AThos MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Il13^tm2Anjm/Il13^tm2Anjm Tg(SFTPC-Il18)AThos/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2	MGI:5688502
cx2	Ifng^tm1Ts/Ifng^tm1Ts Tg(SFTPC-Il18)AThos/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2	MGI:5688500
tg3	Tg(SFTPC-Il18)AThos/0	B6N.Cg-Tg(SFTPC-Il18)AThos	MGI:5688495

Allelic Composition	Il13^tm2Anjm/Il13^tm2Anjm Tg(SFTPC-Il18)AThos/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm2Anjm mutation (6 available); any Il13 mutation (30 available)
Tg(SFTPC-Il18)AThos mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:219136 )

• mice show a decrease in body weight from 16 to 24 weeks of age, however weight loss is less than seen in single transgenic Tg(SFTPC-Il18)AThos mice

respiratory system

abnormal pulmonary alveolus morphology ( J:147547 )

• mean alveolar chord lengths of 14 week old mice is shorter than in single transgenic mice

• however, pulmonary inflammation and emphysematous changes are not seen in the lungs enlarged alveolar macrophages and exudates are not present in the lungs

muscle

decreased skeletal muscle weight ( J:219136 )

• decrease in quadriceps femoris muscle weight at 7 and 16 weeks of age, although muscle is heavier than in single transgenic Tg(SFTPC-Il18)AThos mice and by 25 weeks of age, weight is similar to wild-type mice

• mice show a decrease in gastrocnemius muscle weight at 7 weeks of age but not 16 and 25 weeks of age

skeleton

skeleton phenotype ( J:219136 )

N	• bone mineral density is normal

Allelic Composition	Ifng^tm1Ts/Ifng^tm1Ts Tg(SFTPC-Il18)AThos/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifng^tm1Ts mutation (18 available); any Ifng mutation (49 available)
Tg(SFTPC-Il18)AThos mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lung inflammation ( J:147547 )

• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice

respiratory system

lung inflammation ( J:147547 )

• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice

abnormal pulmonary alveolus morphology ( J:147547 )

• the mean alveolar chord length is greater than in wild-type mice and single Tg(SFTPC-Il18)AThos transgenic mice

emphysema ( J:147547 )

• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice

abnormal lung volume ( J:147547 )

• lung volume is higher than in wild-type or single transgenic mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

enlarged heart ( J:147547 )

• mice over 10 weeks of age exhibit cardiomegaly

heart right ventricle hypertrophy ( J:147547 )

• the right ventricle exhibits hypertrophy in some 8 week old mutants

dilated heart right ventricle ( J:147547 )

• dilation of the right ventricle dimension is seen in aged (15-17 week), but not juvenile, mice

abnormal cardiovascular system physiology ( J:147547 )

• mice show signs of right-sided heart failure with aging

increased right ventricle diastolic pressure ( J:147547 )

• the right ventricular end-diastolic pressure is higher in 20 week old mice

increased right ventricle systolic pressure ( J:147547 )

• the right ventricular systolic pressure is higher in 20 week old mice

pulmonary hypertension ( J:147547 )

• pulmonary hypertension is seen with aging

growth/size/body

enlarged heart ( J:147547 )

• mice over 10 weeks of age exhibit cardiomegaly

heart right ventricle hypertrophy ( J:147547 )

• the right ventricle exhibits hypertrophy in some 8 week old mutants

weight loss ( J:219136 )

• mice show a decrease in body weight from 16 to 24 weeks of age, but not at earlier times

enlarged spleen ( J:147547 )

• moderate splenomegaly

• mice however, do not exhibit enteritis, glomerulonephritis, or hepatitis

hematopoietic system

abnormal spleen morphology ( J:147547 )

• lymphoid follicle is enlarged in spleens

enlarged spleen ( J:147547 )

• moderate splenomegaly

• mice however, do not exhibit enteritis, glomerulonephritis, or hepatitis

homeostasis/metabolism

impaired glucose tolerance ( J:219136 )

• mice exhibit impaired glucose tolerance at 20 weeks of age at 120 minutes, but not at 30 and 60 minutes, after glucose administration, showing higher glucose levels

immune system

abnormal spleen morphology ( J:147547 )

• lymphoid follicle is enlarged in spleens

enlarged spleen ( J:147547 )

• moderate splenomegaly

• mice however, do not exhibit enteritis, glomerulonephritis, or hepatitis

increased interferon-gamma secretion ( J:147547 )

• increase in IFN-gamma production in the lungs

increased interleukin-13 secretion ( J:147547 )

• increase in Il13 production in the lungs

lung inflammation ( J:147547 )

• mild interstitial inflammation in the alveolar wall is seen at around 4 weeks after birth

• inflammatory cells contain increased numbers of mononuclear ells, neutrophils, and eosinophils

• enlarged macrophages and exudates are seen in some pulmonary alveoli

• alveolar macrophages, CD8+ T cells, CD4+ T cells, CD3+ T cells, neutrophils, and eosinophils are increased in the bronchoalveolar lavage fluid; the proportion of CD8+ T cells is greater than that of CD4+ T-cells

muscle

heart right ventricle hypertrophy ( J:147547 )

• the right ventricle exhibits hypertrophy in some 8 week old mutants

decreased skeletal muscle weight ( J:219136 )

• decrease in quadriceps femoris and gastrocnemius muscle weight at 7, 16, and 25 weeks of age

respiratory system

lung inflammation ( J:147547 )

• mild interstitial inflammation in the alveolar wall is seen at around 4 weeks after birth

• inflammatory cells contain increased numbers of mononuclear ells, neutrophils, and eosinophils

• enlarged macrophages and exudates are seen in some pulmonary alveoli

abnormal pulmonary alveolus morphology ( J:147547 )

• mean alveolar chord length is increased in males at 6 and 8 weeks of age, with a greater than 70% increase at 10 weeks of age

• mice show a wider spread of the distribution of chord length in the lungs compared to the narrow distribution in controls

increased pulmonary alveolus wall thickness ( J:147547 )

• aged (24 weeks) mice show thickening of the alveolar walls and interstitium accompanied with severe pulmonary inflammation

overexpanded pulmonary alveolus ( J:147547 )

• alveolar enlargement is seen around 8 weeks of age

emphysema ( J:147547 )

abnormal lung volume ( J:147547 )

• mice over 10 weeks of age exhibit increased lung volumes

• however, lung formation is normal and lung fibrosis is not seen

abnormal lung compliance ( J:147547 )

• static lung compliance is higher than in controls at 11 weeks of age

• static lung compliance in 24 week old mice with severe interstitial inflammation is significantly lower than in controls

skeleton

decreased bone mineral density ( J:219136 )

• decrease in bone mineral density in aged (24 weeks) mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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