Phenotypes associated with this allele

• Allele Symbol: Rbm38^tm1.1Xch
• Allele Name: targeted mutation 1.1, Xinbin Chen
• Allele ID: MGI:5688508
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbm38^tm1.1Xch/Rbm38^tm1.1Xch	involves: C57BL/6 * FVB/N	MGI:5688511
cx2	Rbm38^tm1.1Xch/Rbm38^tm1.1Xch Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:5688514
cx3	Rbm38^tm1.1Xch/Rbm38^tm1.1Xch Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:5688515

Genotype
MGI:5688511

hm1

• Allelic Composition: Rbm38^tm1.1Xch/Rbm38^tm1.1Xch
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:216929 )

• median survival following exposure to 8 gray of whole body gamma-irradiation is 13 days compared to 20 days for wild-type controls

decreased tumor-free survival time ( J:216929 )

• median tumor free survival time is 94 wk compared to 121 wk in wild-type controls

• maximum lifespan is 128 wk compared to 144 wk in wild-type mice

premature aging ( J:216929 )

growth/size/body

weight loss ( J:216929 )

• at 18 months of age

enlarged spleen ( J:216929 )

• seen at 2 months of age and becomes more pronounced with age

adipose tissue

decreased total body fat amount ( J:216929 )

decreased gonadal fat pad weight ( J:216929 )

• relative percentage of gonadal fat vs. body weight is 0.4% compared to 1.8% in wild-type controls

neoplasm

increased tumor incidence ( J:216929 )

• tumors are found in 12 of 23 mice compared to 3 of 17 wild-type controls

increased hepatoma incidence ( J:216929 )

• found in 4 of 23 mice compared to 0 of 17 wild-type controls

increased lymphoma incidence ( J:216929 )

• found in 8 of 23 mice compared to 2 of 17 wild-type controls

increased hemangiosarcoma incidence ( J:216929 )

• found in 2 of 23 mice compared to 0 of 17 wild-type controls

liver/biliary system

increased hepatoma incidence ( J:216929 )

• found in 4 of 23 mice compared to 0 of 17 wild-type controls

hematopoietic system

enlarged spleen ( J:216929 )

• seen at 2 months of age and becomes more pronounced with age

extramedullary hematopoiesis ( J:216929 )

• in the spleen (in ~78% of mice) and liver (in ~26% of mice)

anemia ( J:216929 )

decreased bone marrow cell number ( J:216929 )

• erythroid hypoplasia with a relatively increased ratio of myeloid vs. erythroid lineages

increased megakaryocyte cell number ( J:216929 )

• in the spleen

abnormal erythrocyte morphology ( J:216929 )

decreased hematocrit ( J:216929 )

decreased hemoglobin content ( J:216929 )

increased spleen white pulp amount ( J:216929 )

• striking expansion

integument

spontaneous skin ulceration ( J:216929 )

• at 18 months of age

skeleton

lordokyphosis ( J:216929 )

• pronounced lordokyphosis

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:216929 )

• median survival following exposure to 8 gray of whole body gamma-irradiation is 13 days compared to 20 days for wild-type controls

immune system

enlarged spleen ( J:216929 )

• seen at 2 months of age and becomes more pronounced with age

increased spleen white pulp amount ( J:216929 )

• striking expansion

Genotype
MGI:5688514

cx2

• Allelic Composition: Rbm38^tm1.1Xch/Rbm38^tm1.1Xch; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

mortality/aging

decreased mortality induced by ionizing radiation ( J:216929 )

• median survival following exposure to 8 gray of whole body gamma-irradiation is 34 days similar to mutant mice wild-type for Rbm38

premature death ( J:216929 )

• longest lifespan is 29 weeks, median survival is 19 weeks

neoplasm

abnormal tumor susceptibility ( J:216929 )

• tumor spectrum is significantly different from mutant mice wild-type for Rbm38

• mice do not develop hibernoma or hemangioma

increased lymphoma incidence ( J:216929 )

• compared to mutant mice wild-type for Rbm38 (94.1% vs 60.6%)

decreased tumor incidence ( J:216929 )

• tumor burden is markedly reduced compared to mutant mice wild-type for Rbm38 with no mice developing more than 1 primary tumor

decreased sarcoma incidence ( J:216929 )

• compared to mutant mice wild-type for Rbm38 (5.8% vs 30.3%)

decreased tumor latency ( J:216929 )

• tumor onset is 15 weeks compared to 18 weeks in mutant mice wild-type for Rbm38

homeostasis/metabolism

decreased mortality induced by ionizing radiation ( J:216929 )

• median survival following exposure to 8 gray of whole body gamma-irradiation is 34 days similar to mutant mice wild-type for Rbm38

Genotype
MGI:5688515

cx3

• Allelic Composition: Rbm38^tm1.1Xch/Rbm38^tm1.1Xch; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

mortality/aging

premature death ( J:216929 )

• median survival is 70 weeks, slightly but not statistically significantly longer than in mutant mice wild-type for Rbm38

neoplasm

abnormal tumor susceptibility ( J:216929 )

• tumor spectrum is slightly different from mutant mice wild-type for Rbm38

decreased tumor incidence ( J:216929 )

• 9 of 21 mice do not succumb to tumors compared to 1 of 24 mutant mice wild-type for Rbm38

hematopoietic system

abnormal spleen B cell follicle morphology ( J:216929 )

• splenic follicular hyperplasia in tumor free mice

liver/biliary system

hepatic steatosis ( J:216929 )

• in tumor free mice

immune system

abnormal spleen B cell follicle morphology ( J:216929 )

• splenic follicular hyperplasia in tumor free mice