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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-cat,-Il18)#Thos
transgene insertion, Tomoaki Hoshino
MGI:5688534
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(CAG-cat,-Il18)#Thos/0
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 MGI:5688535


Genotype
MGI:5688535
cn1
Allelic
Composition
Tg(CAG-cat,-Il18)#Thos/0
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cat,-Il18)#Thos mutation (0 available)
Tg(SFTPC-rtTA)5Jaw mutation (4 available)
Tg(tetO-cre)1Jaw mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice administered doxycycline (Dox) exhibit an increase in IFN-gamma production in the lungs
• mice treated with Dox show pulmonary inflammation, with infiltration of mononuclear cells in the alveolar wall and general interstitium, indicating interstitial pneumonia
• however, mice treated with Dox do not exhibit emphysema, swelled alveolar macrophages, hyaline membranes, or proteinaceous debris, and show no evidence of increased lung volumes or cardiomegaly

respiratory system
• mice treated with Dox show pulmonary inflammation, with infiltration of mononuclear cells in the alveolar wall and general interstitium, indicating interstitial pneumonia
• however, mice treated with Dox do not exhibit emphysema, swelled alveolar macrophages, hyaline membranes, or proteinaceous debris, and show no evidence of increased lung volumes or cardiomegaly
• mean alveolar chord length is lower than in wild-type mice





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory