About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-cat,-Il18)#Thos
transgene insertion, Tomoaki Hoshino
MGI:5688534
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(CAG-cat,-Il18)#Thos/0
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 MGI:5688535


Genotype
MGI:5688535
cn1
Allelic
Composition
Tg(CAG-cat,-Il18)#Thos/0
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cat,-Il18)#Thos mutation (0 available)
Tg(SFTPC-rtTA)5Jaw mutation (4 available)
Tg(tetO-cre)1Jaw mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice administered doxycycline (Dox) exhibit an increase in IFN-gamma production in the lungs
• mice treated with Dox show pulmonary inflammation, with infiltration of mononuclear cells in the alveolar wall and general interstitium, indicating interstitial pneumonia
• however, mice treated with Dox do not exhibit emphysema, swelled alveolar macrophages, hyaline membranes, or proteinaceous debris, and show no evidence of increased lung volumes or cardiomegaly

respiratory system
• mice treated with Dox show pulmonary inflammation, with infiltration of mononuclear cells in the alveolar wall and general interstitium, indicating interstitial pneumonia
• however, mice treated with Dox do not exhibit emphysema, swelled alveolar macrophages, hyaline membranes, or proteinaceous debris, and show no evidence of increased lung volumes or cardiomegaly
• mean alveolar chord length is lower than in wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory