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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb3tm1.1Wlbcr
targeted mutation 1.1, Katherine Weilbaecher
MGI:5688572
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr involves: C57BL/6 MGI:5688875
cn2
 		Itgb3tm1Hyn/Itgb3tm1.1Wlbcr
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:5688877
cn3
 		Itgb3tm1Hyn/Itgb3tm1.1Wlbcr
Tg(Pf4-icre)Q3Rsko/0 		involves: 129S2/SvPas * C57BL/6 MGI:5688878


Genotype
MGI:5688875
hm1
Allelic
Composition		 Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb3tm1.1Wlbcr mutation (1 available); any Itgb3 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:224675 )
• mice are viable and fertile




Genotype
MGI:5688877
cn2
Allelic
Composition		 Itgb3tm1Hyn/Itgb3tm1.1Wlbcr
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb3tm1.1Wlbcr mutation (1 available); any Itgb3 mutation (45 available)
Itgb3tm1Hyn mutation (6 available); any Itgb3 mutation (45 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal osteoclast differentiation ( J:224675 )
• osteoclasts exhibit decreased fusion during differentiation

hematopoietic system
abnormal osteoclast morphology ( J:224675 )
• decreased size of multinucleate osteoclasts as compared to controls
• osteoclasts exhibit decreased fusion during differentiation
abnormal osteoclast differentiation ( J:224675 )
• osteoclasts exhibit decreased fusion during differentiation
decreased osteoclast cell number ( J:224675 )
• numbers of osteoclasts are decreased during differentiation

homeostasis/metabolism
decreased collagen level ( J:224675 )
• decreased levels of serum type I collagen as compared to wild type

immune system
abnormal osteoclast morphology ( J:224675 )
• decreased size of multinucleate osteoclasts as compared to controls
• osteoclasts exhibit decreased fusion during differentiation
abnormal osteoclast differentiation ( J:224675 )
• osteoclasts exhibit decreased fusion during differentiation
decreased osteoclast cell number ( J:224675 )
• numbers of osteoclasts are decreased during differentiation

skeleton
abnormal osteoclast morphology ( J:224675 )
• decreased size of multinucleate osteoclasts as compared to controls
• osteoclasts exhibit decreased fusion during differentiation
abnormal osteoclast differentiation ( J:224675 )
• osteoclasts exhibit decreased fusion during differentiation
decreased osteoclast cell number ( J:224675 )
• numbers of osteoclasts are decreased during differentiation
increased bone mineral density ( J:224675 )
• increased bone mineral density is found in 2 and 6 month old mice as compared to controls
increased trabecular bone volume ( J:224675 )
• increased trabecular bone volume in femoral and tibial bones

neoplasm
abnormal tumor pathology ( J:224675 )
• macrophage infiltration is decreased in implanted subcutaneous tumors as compared to tumor implanted controls
abnormal tumor susceptibility ( J:224675 )
• implanted melanoma cells have an increased live cell mass and volume as compared to tumor implanted controls




Genotype
MGI:5688878
cn3
Allelic
Composition		 Itgb3tm1Hyn/Itgb3tm1.1Wlbcr
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb3tm1.1Wlbcr mutation (1 available); any Itgb3 mutation (45 available)
Itgb3tm1Hyn mutation (6 available); any Itgb3 mutation (45 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:224675 )
• 15% of mice die postnatally due to spontaneous bleeding

digestive/alimentary system
gastrointestinal hemorrhage ( J:224675 )
• 85% of 8-13 week old mice exhibit gastrointestinal bleeding

hematopoietic system
decreased hemoglobin content ( J:224675 )
• decreased hemoglobin levels
decreased platelet aggregation ( J:224675 )
• platelet-rich plasma (PRP) does not undergo ADP-induced platelet aggregation

homeostasis/metabolism
abnormal blood coagulation ( J:224675 )
• clot retraction does not occur in platelet-rich plasma (PRP)
decreased platelet aggregation ( J:224675 )
• platelet-rich plasma (PRP) does not undergo ADP-induced platelet aggregation

immune system

cardiovascular system
gastrointestinal hemorrhage ( J:224675 )
• 85% of 8-13 week old mice exhibit gastrointestinal bleeding
intracranial hemorrhage ( J:224675 )
• acute and chronic intracranial bleeding

nervous system
intracranial hemorrhage ( J:224675 )
• acute and chronic intracranial bleeding

growth/size/body
enlarged spleen ( J:224675 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Glanzmann's thrombasthenia DOID:2219 OMIM:273800
 J:224675




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory