Phenotypes associated with this allele

• Allele Symbol: Tlr4^lps-5Btlr
• Allele Name: defective lipopolysaccharide response 5 Bruce Beutler
• Allele ID: MGI:5688583
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr4^lps-5Btlr/Tlr4^lps-5Btlr	C57BL/6J-Tlr4^lps-5Btlr	MGI:5688631

Genotype
MGI:5688631

hm1

• Allelic Composition: Tlr4^lps-5Btlr/Tlr4^lps-5Btlr
• Genetic Background: C57BL/6J-Tlr4^lps-5Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:224666 )

• reduced B cell frequency

decreased memory B cell number ( J:224666 )

• IgD+ B cells

• IgM+ B cells

decreased macrophage cytokine production ( J:224666 )

• mice are deficient in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

decreased tumor necrosis factor secretion ( J:224666 )

• mice are deficient in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

hematopoietic system

decreased B cell number ( J:224666 )

• reduced B cell frequency

decreased memory B cell number ( J:224666 )

• IgD+ B cells

• IgM+ B cells

decreased macrophage cytokine production ( J:224666 )

• mice are deficient in TNF secretion from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)