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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k8m3Btlr
mutation 3, Bruce Beutler
MGI:5688599
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k8m3Btlr/Map3k8m3Btlr C57BL/6J-Map3k8m3Btlr MGI:5688647
ht2
 		Map3k8m3Btlr/Map3k8+ C57BL/6J-Map3k8m3Btlr MGI:5688648


Genotype
MGI:5688647
hm1
Allelic
Composition		 Map3k8m3Btlr/Map3k8m3Btlr
Genetic
Background		 C57BL/6J-Map3k8m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8m3Btlr mutation (0 available); any Map3k8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:224668 )
• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)
decreased tumor necrosis factor secretion ( J:224668 )
• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)

hematopoietic system
decreased macrophage cytokine production ( J:224668 )
• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)




Genotype
MGI:5688648
ht2
Allelic
Composition		 Map3k8m3Btlr/Map3k8+
Genetic
Background		 C57BL/6J-Map3k8m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8m3Btlr mutation (0 available); any Map3k8 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:224668 )
• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)
decreased tumor necrosis factor secretion ( J:224668 )
• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)

hematopoietic system
decreased macrophage cytokine production ( J:224668 )
• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory