About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Malt1m2Btlr
mutation 2, Bruce Beutler
MGI:5688602
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Malt1m2Btlr/Malt1m2Btlr C57BL/6J-Malt1m2Btlr MGI:5688633
ht2
 		Malt1m2Btlr/Malt1+ C57BL/6J-Malt1m2Btlr MGI:5688634


Genotype
MGI:5688633
hm1
Allelic
Composition		 Malt1m2Btlr/Malt1m2Btlr
Genetic
Background		 C57BL/6J-Malt1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1m2Btlr mutation (0 available); any Malt1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:224671 )
• mice show diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished
impaired humoral immune response ( J:224671 )
• mice show diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished

hematopoietic system
decreased IgG level ( J:224671 )
• mice show diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished




Genotype
MGI:5688634
ht2
Allelic
Composition		 Malt1m2Btlr/Malt1+
Genetic
Background		 C57BL/6J-Malt1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1m2Btlr mutation (0 available); any Malt1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished
impaired humoral immune response ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished

hematopoietic system
decreased IgM level ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory