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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Malt1m3Btlr
mutation 3, Bruce Beutler
MGI:5688603
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Malt1m3Btlr/Malt1m3Btlr C57BL/6J-Malt1m3Btlr MGI:5688640
ht2
 		Malt1m3Btlr/Malt1+ C57BL/6J-Malt1m3Btlr MGI:5688641


Genotype
MGI:5688640
hm1
Allelic
Composition		 Malt1m3Btlr/Malt1m3Btlr
Genetic
Background		 C57BL/6J-Malt1m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1m3Btlr mutation (0 available); any Malt1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:224672 )
• mice show diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished
impaired humoral immune response ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished
• mice show diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system
decreased IgG level ( J:224672 )
• mice show diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished




Genotype
MGI:5688641
ht2
Allelic
Composition		 Malt1m3Btlr/Malt1+
Genetic
Background		 C57BL/6J-Malt1m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1m3Btlr mutation (0 available); any Malt1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished
impaired humoral immune response ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished

hematopoietic system
decreased IgM level ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory