Phenotypes associated with this allele

• Allele Symbol: Enho^tm1Cmwo
• Allele Name: targeted mutation 1, Chi-Ming Wong
• Allele ID: MGI:5688642
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Enho^tm1Cmwo/Enho^tm1Cmwo	B6.129S1-Enho^tm1Cmwo	MGI:5688645

Genotype
MGI:5688645

hm1

• Allelic Composition: Enho^tm1Cmwo/Enho^tm1Cmwo
• Genetic Background: B6.129S1-Enho^tm1Cmwo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:216870 )

N • no change in latency to fall from a hanging wire

decreased food intake ( J:216870 )

• slight, especially during the dark period

impaired coordination ( J:216870 )

• on a rotarod

abnormal locomotor activation ( J:216870 )

• in a forced running test increase in the number and time of shocks and a decrease in distance covered

decreased locomotor activity ( J:216870 )

• significant reduction in locomotor activity, especially during the dark period

nervous system

abnormal Purkinje cell morphology ( J:216870 )

• density of VGlut1-positive puncta is slightly but significantly decreased in the cerebellum

adipose tissue

adipose tissue phenotype ( J:216870 )

N • adiposity is similar to controls on standard chow and high fat diet

growth/size/body

growth/size/body region phenotype ( J:216870 )

N • body weight is similar to controls on standard chow and high fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:216870 )

N • no significant changes in glucose tolerance and insulin sensitivity are seen