Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-cre)#Tfln
• Allele Name: transgene insertion, Timothy F Lane
• Allele ID: MGI:5688657
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53^tm1Brn/Trp53^+ Tg(MMTV-cre)#Tfln/0	involves: 129P2/OlaHsd	MGI:5000480
cn2	Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+ Tg(MMTV-cre)#Tfln/0 Trp53^tm1Brn/Trp53^+	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:5000479
cn3	Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+ Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Tfln/0	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:5000478
cn4	Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Tfln/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5752199
cn5	Pten^tm2Mak/Pten^tm2Mak Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Tfln/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5752193
cn6	Pten^tm2Mak/Pten^tm2Mak Tg(MMTV-cre)#Tfln/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5752189
cn7	Pten^tm1Hwu/Pten^tm1Hwu Tg(MMTV-cre)#Tfln/0	involves: 129S4/SvJae	MGI:5688693
cn8	Gt(ROSA)26Sor^tm2(Pik3ca)Egan/Gt(ROSA)26Sor^+ Tg(MMTV-cre)#Tfln/0	involves: 129S6/SvEvTac	MGI:5000482
cn9	Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+ Tg(MMTV-cre)#Tfln/0	involves: 129S6/SvEvTac	MGI:5000477

Genotype
MGI:5000480

cn1

• Allelic Composition: Trp53^tm1Brn/Trp53⁺; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:170898 )

• 92% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or poorly differentiated adenocarcinoma

increased mammary adenocarcinoma incidence ( J:170898 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170898 )

• 92% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or poorly differentiated adenocarcinoma

increased mammary adenocarcinoma incidence ( J:170898 )

integument

increased mammary gland tumor incidence ( J:170898 )

• 92% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or poorly differentiated adenocarcinoma

increased mammary adenocarcinoma incidence ( J:170898 )

Genotype
MGI:5000479

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)#Tfln/0; Trp53^tm1Brn/Trp53⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

mortality/aging

premature death ( J:170898 )

• survival is reduced compared to mutant mice wild-type for Trp53

neoplasm

increased mammary gland tumor incidence ( J:170898 )

• 80% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma

• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

increased mammary adenocarcinoma incidence ( J:170898 )

increased lymphoma incidence ( J:170898 )

• at a lower rate than in mutant mice homozygous for Trp53^tm1Brn

increased T cell derived lymphoma incidence ( J:170898 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:170898 )

increased mammary gland tumor incidence ( J:170898 )

• 80% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma

• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

increased mammary adenocarcinoma incidence ( J:170898 )

integument

increased mammary gland tumor incidence ( J:170898 )

• 80% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma

• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

increased mammary adenocarcinoma incidence ( J:170898 )

immune system

increased T cell derived lymphoma incidence ( J:170898 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:170898 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:170898

Genotype
MGI:5000478

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

mortality/aging

premature death ( J:170898 )

• most die early with lymphoma/thymoma

neoplasm

increased mammary gland tumor incidence ( J:170898 )

• some mice have small mammary tumors

increased lymphoma incidence ( J:170898 )

increased T cell derived lymphoma incidence ( J:170898 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:170898 )

increased mammary gland tumor incidence ( J:170898 )

• some mice have small mammary tumors

integument

increased mammary gland tumor incidence ( J:170898 )

• some mice have small mammary tumors

immune system

increased T cell derived lymphoma incidence ( J:170898 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:170898 )

Genotype
MGI:5752199

cn4

• Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 16.9 months

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 30% of mammary tumors are mixed mesenchymal adenocarcinomas and 10% are adenosquamous carcinoma

increased spindle cell carcinoma incidence ( J:224955 )

♀ • about 30% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer

increased myoepithelioma incidence ( J:224955 )

♀ • 30% of mammary tumors are adenomyoepithelioma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 16.9 months

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 30% of mammary tumors are mixed mesenchymal adenocarcinomas and 10% are adenosquamous carcinoma

integument

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 16.9 months

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 30% of mammary tumors are mixed mesenchymal adenocarcinomas and 10% are adenosquamous carcinoma

Genotype
MGI:5752193

cn5

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Trp53^tm1Brn/Trp53^tm1Brn; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 11.3 months

♀ • expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

increased spindle cell carcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer

increased myoepithelioma incidence ( J:224955 )

♀ • 17% of mammary tumors are adenomyoepithelioma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 11.3 months

♀ • expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

integument

increased mammary gland tumor incidence ( J:224955 )

♀ • females develop mammary tumors with a latency of 11.3 months

♀ • expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • about 72% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:224955

Genotype
MGI:5752189

cn6

• Allelic Composition: Pten^tm2Mak/Pten^tm2Mak; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:224955 )

♀ • mice develop mammary tumors after a latency of 26.4 months with 70% penetrance

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 25% of mammary tumors are adenosquamous carcinoma and 4% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

♀ • pregnancy accelerates tumor formation

increased spindle cell carcinoma incidence ( J:224955 )

♀ • 4% of mammary tumors are spindle-cell/adenosarcoma

increased myoepithelioma incidence ( J:224955 )

♀ • 67% of mammary tumors are adenomyoepithelioma

integument

increased mammary gland tumor incidence ( J:224955 )

♀ • mice develop mammary tumors after a latency of 26.4 months with 70% penetrance

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 25% of mammary tumors are adenosquamous carcinoma and 4% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

♀ • pregnancy accelerates tumor formation

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:224955 )

♀ • mice develop mammary tumors after a latency of 26.4 months with 70% penetrance

increased mammary adenocarcinoma incidence ( J:224955 )

♀ • 25% of mammary tumors are adenosquamous carcinoma and 4% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

♀ • pregnancy accelerates tumor formation

Genotype
MGI:5688693

cn7

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129S4/SvJae

reproductive system

abnormal mammary gland growth during pregnancy ( J:78415 )

♀ • mammary glands exhibit much larger lobules on the 13th day of pregnancy

neoplasm

increased mammary gland tumor incidence ( J:78415 )

• develop mammary gland tumors as early as 2 months of age

• tumor incidence is increased with shortened latencies in multiparous females

increased fibroadenoma incidence ( J:78415 )

• benign fibroadenomas

increased mammary adenocarcinoma incidence ( J:78415 )

• pleiomorphic adenocarcinomas

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:78415 )

♀ • delay in the normal involution process and a decrease in cell apoptosis

abnormal mammary gland growth during pregnancy ( J:78415 )

♀ • mammary glands exhibit much larger lobules on the 13th day of pregnancy

abnormal mammary gland epithelium morphology ( J:78415 )

♀ • virgin mammary duct epithelium exhibits increased proliferation at 5 weeks and 14 weeks of age

abnormal branching of the mammary ductal tree ( J:78415 )

♀ • virgin mammary ducts develop excessive side branches or small protrusions at 6 weeks of age

mammary gland duct hyperplasia ( J:78415 )

♀ • mammary ducts grow much faster during puberty than in controls, leading to earlier occupancy of the fat pad and earlier disappearance of the terminal end buds than in controls

abnormal mammary gland lobule morphology ( J:78415 )

♀ • virgin glands contain many lobuloalveolar buds which are normally seen during pregnancy indicating an acceleration in lobuloalveolar-like precocious differentiation

increased mammary gland tumor incidence ( J:78415 )

• develop mammary gland tumors as early as 2 months of age

• tumor incidence is increased with shortened latencies in multiparous females

increased fibroadenoma incidence ( J:78415 )

• benign fibroadenomas

increased mammary adenocarcinoma incidence ( J:78415 )

• pleiomorphic adenocarcinomas

mammary gland hyperplasia ( J:78415 )

♀ • mammary glands after one pregnancy show intra-luminal focal cellular hyperplasia and dysplasia

integument

abnormal involution of the mammary gland ( J:78415 )

♀ • delay in the normal involution process and a decrease in cell apoptosis

abnormal mammary gland growth during pregnancy ( J:78415 )

♀ • mammary glands exhibit much larger lobules on the 13th day of pregnancy

abnormal mammary gland epithelium morphology ( J:78415 )

♀ • virgin mammary duct epithelium exhibits increased proliferation at 5 weeks and 14 weeks of age

abnormal branching of the mammary ductal tree ( J:78415 )

♀ • virgin mammary ducts develop excessive side branches or small protrusions at 6 weeks of age

mammary gland duct hyperplasia ( J:78415 )

♀ • mammary ducts grow much faster during puberty than in controls, leading to earlier occupancy of the fat pad and earlier disappearance of the terminal end buds than in controls

abnormal mammary gland lobule morphology ( J:78415 )

♀ • virgin glands contain many lobuloalveolar buds which are normally seen during pregnancy indicating an acceleration in lobuloalveolar-like precocious differentiation

increased mammary gland tumor incidence ( J:78415 )

• develop mammary gland tumors as early as 2 months of age

• tumor incidence is increased with shortened latencies in multiparous females

increased fibroadenoma incidence ( J:78415 )

• benign fibroadenomas

increased mammary adenocarcinoma incidence ( J:78415 )

• pleiomorphic adenocarcinomas

mammary gland hyperplasia ( J:78415 )

♀ • mammary glands after one pregnancy show intra-luminal focal cellular hyperplasia and dysplasia

Genotype
MGI:5000482

cn8

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Pik3ca)Egan}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129S6/SvEvTac

normal phenotype

no abnormal phenotype detected ( J:170898 )

Genotype
MGI:5000477

cn9

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)#Tfln/0
• Genetic Background: involves: 129S6/SvEvTac

mortality/aging

premature death ( J:170898 )

• survival time is increased compared to mutant mice carrying Tg(MMTV-cre)1Mam

neoplasm

increased tumor incidence ( J:170898 )

• develop a less diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)1Mam

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 69% of mice have palpable mammary tumors at the time of death

• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

• isolated lung metastases are seen in rare cases

increased mammary adenocarcinoma incidence ( J:170898 )

integument

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 69% of mice have palpable mammary tumors at the time of death

• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

• isolated lung metastases are seen in rare cases

increased mammary adenocarcinoma incidence ( J:170898 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 69% of mice have palpable mammary tumors at the time of death

• tumors are typically either adenosquamous carcinoma or adenomyoepithioma

• isolated lung metastases are seen in rare cases

increased mammary adenocarcinoma incidence ( J:170898 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:170898