All Phenotypes Meikin<tm1Yow> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Meikin^tm1Yow/Meikin^tm1Yow	involves: C57BL/6	MGI:5688714
cx2	Meikin^tm1Yow/Meikin^tm1Yow Mlh1^tm1Lisk/Mlh1^tm1Lisk	involves: 129S7/SvEvBrd * C57BL/6	MGI:5688722

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:216866 )

• mature sperm are rarely seen in the epididymis

abnormal spermatid morphology ( J:216866 )

• enlarged

abnormal chromosomal synapsis ( J:216866 )

• chromosome alignment in metaphase II is largely disrupted in oocytes

• sister kinetochore pairs distance of prometaphase I chromosomes is significantly increased

abnormal female meiosis ( J:216866 )

• chromosome congression is partly perturbed

• many pairs of sister kinetochores start to split at the onset of anaphase unlike in wild-type controls

impaired polar body extrusion ( J:216866 )

• cultured oocytes extrude the first polar body on average 2 h later than wild-type controls

abnormal male meiosis ( J:216866 )

• kinetochore separation defects during anaphase I in spermatocytes

• less severe than in mice homozygous for Sgol2a^{Gt(D025B05)Wrst}

arrest of male meiosis ( J:216866 )

• meiosis II does not appear to occur

female infertility ( J:216866 )

male infertility ( J:216866 )

cellular

oligozoospermia ( J:216866 )

• mature sperm are rarely seen in the epididymis

abnormal spermatid morphology ( J:216866 )

• enlarged

abnormal chromosomal synapsis ( J:216866 )

• chromosome alignment in metaphase II is largely disrupted in oocytes

• sister kinetochore pairs distance of prometaphase I chromosomes is significantly increased

abnormal female meiosis ( J:216866 )

• chromosome congression is partly perturbed

• many pairs of sister kinetochores start to split at the onset of anaphase unlike in wild-type controls

impaired polar body extrusion ( J:216866 )

• cultured oocytes extrude the first polar body on average 2 h later than wild-type controls

abnormal male meiosis ( J:216866 )

• kinetochore separation defects during anaphase I in spermatocytes

• less severe than in mice homozygous for Sgol2a^{Gt(D025B05)Wrst}

arrest of male meiosis ( J:216866 )

• meiosis II does not appear to occur

Allelic Composition	Meikin^tm1Yow/Meikin^tm1Yow Mlh1^tm1Lisk/Mlh1^tm1Lisk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meikin^tm1Yow mutation (0 available); any Meikin mutation (19 available)
Mlh1^tm1Lisk mutation (2 available); any Mlh1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:216866 )

• univalents congressed at the metaphase plate and sister kinetochore pairs separated by >0.6 um are seen more frequently in oocytes from double mutant mice than in mutant mice wild-type for Meikin

• mono-orientation defect in spermatocytes

cellular

abnormal chromosomal synapsis ( J:216866 )

• univalents congressed at the metaphase plate and sister kinetochore pairs separated by >0.6 um are seen more frequently in oocytes from double mutant mice than in mutant mice wild-type for Meikin

• mono-orientation defect in spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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