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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Meikintm1Yow
targeted mutation 1, Yoshinori Watanabe
MGI:5688710
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Meikintm1Yow/Meikintm1Yow involves: C57BL/6 MGI:5688714
cx2
Meikintm1Yow/Meikintm1Yow
Mlh1tm1Lisk/Mlh1tm1Lisk
involves: 129S7/SvEvBrd * C57BL/6 MGI:5688722


Genotype
MGI:5688714
hm1
Allelic
Composition
Meikintm1Yow/Meikintm1Yow
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meikintm1Yow mutation (0 available); any Meikin mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mature sperm are rarely seen in the epididymis
• chromosome alignment in metaphase II is largely disrupted in oocytes
• sister kinetochore pairs distance of prometaphase I chromosomes is significantly increased
• chromosome congression is partly perturbed
• many pairs of sister kinetochores start to split at the onset of anaphase unlike in wild-type controls
• cultured oocytes extrude the first polar body on average 2 h later than wild-type controls
• kinetochore separation defects during anaphase I in spermatocytes
• less severe than in mice homozygous for Sgol2aGt(D025B05)Wrst
• meiosis II does not appear to occur

cellular
• mature sperm are rarely seen in the epididymis
• chromosome alignment in metaphase II is largely disrupted in oocytes
• sister kinetochore pairs distance of prometaphase I chromosomes is significantly increased
• chromosome congression is partly perturbed
• many pairs of sister kinetochores start to split at the onset of anaphase unlike in wild-type controls
• cultured oocytes extrude the first polar body on average 2 h later than wild-type controls
• kinetochore separation defects during anaphase I in spermatocytes
• less severe than in mice homozygous for Sgol2aGt(D025B05)Wrst
• meiosis II does not appear to occur




Genotype
MGI:5688722
cx2
Allelic
Composition
Meikintm1Yow/Meikintm1Yow
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meikintm1Yow mutation (0 available); any Meikin mutation (19 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• univalents congressed at the metaphase plate and sister kinetochore pairs separated by >0.6 um are seen more frequently in oocytes from double mutant mice than in mutant mice wild-type for Meikin
• mono-orientation defect in spermatocytes

cellular
• univalents congressed at the metaphase plate and sister kinetochore pairs separated by >0.6 um are seen more frequently in oocytes from double mutant mice than in mutant mice wild-type for Meikin
• mono-orientation defect in spermatocytes





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory