Analysis Tools|
Allele Symbol Allele Name Allele ID |
Slc12a6tm2.1Dlp targeted mutation 2.1, Eric Delpire MGI:5688752 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice display no locomotor deficit in the accelerated rotarod and open field tests and show a normal response latency to heat-evoked nociceptive stimuli in a hot plate assay
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the accelerated rotarod test, mice fall significantly faster than control mice (<150 sec versus >250 sec, respectively) but are able to improve their performance
• however, no significant difference in locomotor activity is noted in the open field test, despite a trend towards hyperactivity
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• in the spinal cord, dorsal root ganglia exhibit large vacuoles as well as many structures containing dense material that is parvalbumin immunoreactive
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice display no locomotor deficit in the accelerated rotarod and open field tests relative to control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• surprisingly, mice display no locomotor deficit in the accelerated rotarod and open field tests relative to control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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