All Phenotypes Pkn3<tm1.1Mrl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pkn3^tm1.1Mrl
targeted mutation 1.1, Merck Research Laboratory
MGI:5688854

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	B6.Cg-Pkn3^tm1.1Mrl Commd10^{Tg(Vav1-icre)A2Kio}	MGI:5688866
cn2	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Pten^tm1Hwu/Pten^tm1Hwu Tg(CD2-icre)4Kio/0	involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5688869
cn3	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Pten^tm1Hwu/Pten^tm1Hwu Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:5688867
cn4	Pkn3^tm1.1Mrl/Pkn3⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:5688868
cn5	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA/J	MGI:5688862

Allelic Composition	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	B6.Cg-Pkn3^tm1.1Mrl Commd10^{Tg(Vav1-icre)A2Kio}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (4 available); any Commd10 mutation (25 available)
Pkn3^tm1.1Mrl mutation (0 available); any Pkn3 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:216983 )

N	• hematopoietic stem cell numbers are similar to controls at 6-8 weeks of age and cells perform similar to control cells in a competitive transplantation assay

Allelic Composition	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Pten^tm1Hwu/Pten^tm1Hwu Tg(CD2-icre)4Kio/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn3^tm1.1Mrl mutation (0 available); any Pkn3 mutation (54 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (89 available)
Tg(CD2-icre)4Kio mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:216983 )

N	• thymus weight is similar to controls at 6-8 weeks of age unlike in mutant mice wild-type for Pkn3

Allelic Composition	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Pten^tm1Hwu/Pten^tm1Hwu Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:216983 )

• lifespan after pIpC treatment is shorter than in controls but longer than in mutant nice with one wild-type Pkn3 allele

neoplasm

increased hemolymphoid system tumor incidence ( J:216983 )

• develop myeloproliferative neoplasms in the spleen 2 weeks after pIpC treatment

increased acute lymphoblastic leukemia incidence ( J:216983 )

• all eventually develop T cell acute lymphoblastic leukemia after pIpC treatment at 6 weeks of age

hematopoietic system

enlarged thymus ( J:216983 )

• at 2 weeks after pIpC treatment

• thymus is smaller than in mutant mice with one wild-type Pkn3 allele

enlarged spleen ( J:216983 )

• at 2 weeks after pIpC treatment

extramedullary hematopoiesis ( J:216983 )

• increase in the number of hematopoietic stem cells in the spleen 2 weeks after pIpC treatment

endocrine/exocrine glands

enlarged thymus ( J:216983 )

• at 2 weeks after pIpC treatment

• thymus is smaller than in mutant mice with one wild-type Pkn3 allele

immune system

enlarged thymus ( J:216983 )

• at 2 weeks after pIpC treatment

• thymus is smaller than in mutant mice with one wild-type Pkn3 allele

enlarged spleen ( J:216983 )

• at 2 weeks after pIpC treatment

growth/size/body

enlarged spleen ( J:216983 )

• at 2 weeks after pIpC treatment

Allelic Composition	Pkn3^tm1.1Mrl/Pkn3⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:216983 )

• lifespan after pIpC treatment is shorter than in controls and in mutant nice with no wild-type Pkn3 alleles

neoplasm

increased hemolymphoid system tumor incidence ( J:216983 )

• develop myeloproliferative neoplasms in the spleen 2 weeks after pIpC treatment

increased acute lymphoblastic leukemia incidence ( J:216983 )

• all eventually develop T cell acute lymphoblastic leukemia after pIpC treatment at 6 weeks of age

hematopoietic system

enlarged thymus ( J:216983 )

• at 2 weeks after pIpC treatment

enlarged spleen ( J:216983 )

• at 2 weeks after pIpC treatment

extramedullary hematopoiesis ( J:216983 )

• increase in the number of hematopoietic stem cells in the spleen 2 weeks after pIpC treatment

endocrine/exocrine glands

enlarged thymus ( J:216983 )

• at 2 weeks after pIpC treatment

immune system

enlarged thymus ( J:216983 )

• at 2 weeks after pIpC treatment

enlarged spleen ( J:216983 )

• at 2 weeks after pIpC treatment

growth/size/body

enlarged spleen ( J:216983 )

• at 2 weeks after pIpC treatment

Allelic Composition	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn3^tm1.1Mrl mutation (0 available); any Pkn3 mutation (54 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:216983 )

N	• peripheral and bone marrow hematopoietic cell counts are similar to controls at 8 weeks after pIpC treatment

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