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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcng4tm1.1(cre)Jrs
targeted mutation 1.1, Joshua R Sanes
MGI:5688863
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cdh8tm1Mta/Cdh8tm1Mta
Kcng4tm1.1(cre)Jrs/Kcng4+
Tg(Thy1-EYFP)15Jrs/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5699359
cn2
 		Cdh9tm1b(KOMP)Wtsi/Cdh9tm1b(KOMP)Wtsi
Kcng4tm1.1(cre)Jrs/Kcng4+
Tg(Thy1-EYFP)15Jrs/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA * FVB/N MGI:6147651


Genotype
MGI:5699359
cn1
Allelic
Composition		 Cdh8tm1Mta/Cdh8tm1Mta
Kcng4tm1.1(cre)Jrs/Kcng4+
Tg(Thy1-EYFP)15Jrs/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh8tm1Mta mutation (0 available); any Cdh8 mutation (53 available)
Kcng4tm1.1(cre)Jrs mutation (1 available); any Kcng4 mutation (24 available)
Tg(Thy1-EYFP)15Jrs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:214586 )
N
• axonal arbors in retinal type 5 bipolar cells (BC5)

vision/eye
vision/eye phenotype ( J:214586 )
N
• axonal arbors in retinal type 5 bipolar cells (BC5)




Genotype
MGI:6147651
cn2
Allelic
Composition		 Cdh9tm1b(KOMP)Wtsi/Cdh9tm1b(KOMP)Wtsi
Kcng4tm1.1(cre)Jrs/Kcng4+
Tg(Thy1-EYFP)15Jrs/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh9tm1b(KOMP)Wtsi mutation (0 available); any Cdh9 mutation (46 available)
Kcng4tm1.1(cre)Jrs mutation (1 available); any Kcng4 mutation (24 available)
Tg(Thy1-EYFP)15Jrs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:214586 )
N
• axonal arbors in ON-OFF direction-selective ganglion cells (ooDSGC), starburst amacrine cells (SAC), rod bipolar cells (BC), type 3a OFF BC, tyrosine-hydroxylase-positive wide-field amacrine cells, and Vglut3-positive narrow-field amacrine cells
abnormal retina bipolar cell morphology ( J:214586 )
• one-third of BC5 cells bear monostratified axonal arbors displaced into outer half of inner plexiform layer (IPL)
• two-thirds of BC5 cells bear monostratified axonal arbors in normal sublamina
• BC5 cell axonal arbors bistratified: distributed between two sublaminae

vision/eye
vision/eye phenotype ( J:214586 )
N
• axonal arbors in ON-OFF direction-selective ganglion cells (ooDSGC), starburst amacrine cells (SAC), rod bipolar cells (BC), type 3a OFF BC, tyrosine-hydroxylase-positive wide-field amacrine cells, and Vglut3-positive narrow-field amacrine cells
abnormal retina bipolar cell morphology ( J:214586 )
• one-third of BC5 cells bear monostratified axonal arbors displaced into outer half of inner plexiform layer (IPL)
• two-thirds of BC5 cells bear monostratified axonal arbors in normal sublamina
• BC5 cell axonal arbors bistratified: distributed between two sublaminae




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory