Analysis Tools
behavior/neurological
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• DBA/2J homozygous for this point mutation consume 3.8 and 6.6 fold more methamphetamine per Kg at 20 and 40 mg/L, respectively, than do C57BL/6J mice
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Allele Symbol Allele Name Allele ID |
Taar1m1J mutation 1, Jackson MGI:5688955 |
| Summary |
3 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• DBA/2J homozygous for this point mutation consume 3.8 and 6.6 fold more methamphetamine per Kg at 20 and 40 mg/L, respectively, than do C57BL/6J mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice of C57BL/6J x DBA/2J segregating background populations selected for high consumption of methamphetamine are homozygous for this point mutation while mice from populations selected for low methamphetamine consumption are found to be heterozgyous or wild-type (C57BL/6J allele)
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• mice of C57BL/6J x DBA/2J segregating background populations homozygous for this point mutation respond to methamphetamine treatment, at all doses of 1 to 16 mg/kg, with increased core body temperature
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• populations of C57BL/6J x DBA/2J segregating background mice that are heterozgyous or wild-type for the C57BL/6J-derived allele respond to methamphetamine treatment with a hypothermic response to all doses from 1 to 16 mg/kg, while those homozygous for the DBA/2J-derived m1J allele have a hyperthermic response
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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