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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Taar1m1J
mutation 1, Jackson
MGI:5688955
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Taar1m1J/Taar1m1J DBA/2J MGI:5693289
hm2
 		Taar1m1J/Taar1m1J involves: C57BL/6J * DBA/2J MGI:5693290
ht3
 		Taar1m1J/Taar1+ involves: C57BL/6J * DBA/2J MGI:5693298


Genotype
MGI:5693289
hm1
Allelic
Composition		 Taar1m1J/Taar1m1J
Genetic
Background		 DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taar1m1J mutation (4 available); any Taar1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
enhanced behavioral response to addictive substance ( J:224677 )
• DBA/2J homozygous for this point mutation consume 3.8 and 6.6 fold more methamphetamine per Kg at 20 and 40 mg/L, respectively, than do C57BL/6J mice




Genotype
MGI:5693290
hm2
Allelic
Composition		 Taar1m1J/Taar1m1J
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taar1m1J mutation (4 available); any Taar1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
enhanced behavioral response to addictive substance ( J:224677 )
• mice of C57BL/6J x DBA/2J segregating background populations selected for high consumption of methamphetamine are homozygous for this point mutation while mice from populations selected for low methamphetamine consumption are found to be heterozgyous or wild-type (C57BL/6J allele)

homeostasis/metabolism
abnormal physiological response to xenobiotic ( J:224677 )
• mice of C57BL/6J x DBA/2J segregating background populations homozygous for this point mutation respond to methamphetamine treatment, at all doses of 1 to 16 mg/kg, with increased core body temperature




Genotype
MGI:5693298
ht3
Allelic
Composition		 Taar1m1J/Taar1+
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taar1m1J mutation (4 available); any Taar1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal physiological response to xenobiotic ( J:224677 )
• populations of C57BL/6J x DBA/2J segregating background mice that are heterozgyous or wild-type for the C57BL/6J-derived allele respond to methamphetamine treatment with a hypothermic response to all doses from 1 to 16 mg/kg, while those homozygous for the DBA/2J-derived m1J allele have a hyperthermic response




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory