Phenotypes associated with this allele

• Allele Symbol: Csf1r^tm1.1Jwp
• Allele Name: targeted mutation 1.1, Jeffrey W Pollard
• Allele ID: MGI:5689434
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Csf1r^tm1.1Jwp/Csf1r^tm1.1Jwp	involves: 129/Sv * C57BL/6J * FVB/N * SJL	MGI:3653677

Genotype
MGI:3653677

cn1

• Allelic Composition: Csf1r^tm1.1Jwp/Csf1r^tm1.1Jwp
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:110981 )

• many homozygotes die by 6 weeks of age, particularly the females as only 2 survived past 5 weeks of age

growth/size/body

absent teeth ( J:110981 )

• mice homozygous for the conditional deletion are toothless

round snout ( J:110981 )

• snouts are rounded

decreased body size ( J:110981 )

• both males and females are severely growth retarded

craniofacial

absent teeth ( J:110981 )

• mice homozygous for the conditional deletion are toothless

round snout ( J:110981 )

• snouts are rounded

skeleton

abnormal skeleton morphology ( J:110981 )

• overall skeleton is smaller than in wild-type

absent teeth ( J:110981 )

• mice homozygous for the conditional deletion are toothless

increased bone mineral density ( J:110981 )

• mandible is of higher density and mice have compacted skull structure; higher bone density at the metaphyses is also apparent

osteoporosis ( J:110981 )

• mice exhibit osteoporosis similar to Csf1^op mice; the tail vertebrae are truncated and dense