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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx3tm3Yg
targeted mutation 3, Yoram Groner
MGI:5689483
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Runx3tm3Yg/Runx3tm3Yg
Tg(Pou4f1-cre/ERT2)2Jiz/0 		involves: C57BL/6 MGI:7281829
cn2
 		Runx3tm3Yg/Runx3tm3Yg
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6J * CBA/J MGI:7281828
cn3
 		Runx3tm3Yg/Runx3tm3Yg
Tg(Col2a1-cre)1Bhr/0 		involves: C57BL/6 * SJL MGI:5689564
cn4
 		Runx3tm3Yg/Runx3tm3Yg
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: CD-1 MGI:5689563
cn5
 		Runx3tm3Yg/Runx3tm3Yg
Tg(Col1a1-cre)1Kry/0 		involves: FVB/N MGI:5689556
cn6
 		Runx2tm1Mjo/Runx2+
Runx3tm3Yg/Runx3tm3Yg
Tg(Col1a1-cre)1Kry/0 		involves: FVB/N MGI:5689562
cn7
 		Runx3tm3Yg/Runx3tm3Yg
Tg(Scx-GFP)1Stzr/0 		Not Specified MGI:7281800


Genotype
MGI:7281829
cn1
Allelic
Composition		 Runx3tm3Yg/Runx3tm3Yg
Tg(Pou4f1-cre/ERT2)2Jiz/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation (0 available); any Runx3 mutation (27 available)
Tg(Pou4f1-cre/ERT2)2Jiz mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:243559 )
• severe
abnormal gait ( J:243559 )
• severely impaired gait pattern
• posterior placement of forelimbs and uncoordinated limb placement
• at 3 months of age only a small decrease in gait regularity is seen

skeleton
scoliosis ( J:243559 )
• mild scoliosis with about a 40% incidence
• bend is to the right of the coronal plane

nervous system
abnormal proprioceptive neuron morphology ( J:243559 )
• decreased number of TrkC expressing proprioceptive neurons

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
idiopathic scoliosis DOID:0060250 J:243559




Genotype
MGI:7281828
cn2
Allelic
Composition		 Runx3tm3Yg/Runx3tm3Yg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Runx3tm3Yg mutation (0 available); any Runx3 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:243559 )
• severe
abnormal gait ( J:243559 )
• severely impaired gait pattern
• posterior placement of forelimbs and uncoordinated limb placement
• at 3 months of age gait regularity is substantially decreased

skeleton
scoliosis ( J:243559 )
• more pronounced curvature compared to mice with Tg(Pou4f1-cre/ERT2)2Jiz mediated recombination with about a 75% incidence
• bend is to the right of the coronal plane

nervous system
absent proprioceptive neurons ( J:243559 )
• absence of TrkC expressing neurons

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
idiopathic scoliosis DOID:0060250 J:243559




Genotype
MGI:5689564
cn3
Allelic
Composition		 Runx3tm3Yg/Runx3tm3Yg
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation (0 available); any Runx3 mutation (27 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body height ( J:224290 )
• 2 of 7 mutants exhibit shorter stature

skeleton
skeleton phenotype ( J:224290 , J:243559 )
N
• mice show no differences in bone development or structural parameters from wild-type mice (J:224290)
• do not display scoliosis at 3 months of age (J:243559)




Genotype
MGI:5689563
cn4
Allelic
Composition		 Runx3tm3Yg/Runx3tm3Yg
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation (0 available); any Runx3 mutation (27 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:224290 )
• low survival rates

growth/size/body
decreased body size ( J:224290 )
• severe congenital dwarfism




Genotype
MGI:5689556
cn5
Allelic
Composition		 Runx3tm3Yg/Runx3tm3Yg
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation (0 available); any Runx3 mutation (27 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body mass index ( J:224290 )
• 20-50% lower body mass
decreased body size ( J:224290 )
• dwarfism
decreased body weight ( J:224290 )
decreased body height ( J:224290 )
• short stature that persists throughout life

limbs/digits/tail
decreased diameter of femur ( J:224290 )
• 21.7% lower bone thickness of 23 day old femurs
decreased femoral compact bone area ( J:224290 )
• 25% smaller cortical area of 23 day old femurs

skeleton
skeleton phenotype ( J:243559 )
• do not display scoliosis at 3 months of age
decreased diameter of femur ( J:224290 )
• 21.7% lower bone thickness of 23 day old femurs
decreased femoral compact bone area ( J:224290 )
• 25% smaller cortical area of 23 day old femurs
decreased bone mineral content ( J:224290 )
• 27.1% reduction in bone mineral content in 23 day old femurs




Genotype
MGI:5689562
cn6
Allelic
Composition		 Runx2tm1Mjo/Runx2+
Runx3tm3Yg/Runx3tm3Yg
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx2tm1Mjo mutation (0 available); any Runx2 mutation (44 available)
Runx3tm3Yg mutation (0 available); any Runx3 mutation (27 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:224290 )
• dwarfism
decreased body height ( J:224290 )
• short stature




Genotype
MGI:7281800
cn7
Allelic
Composition		 Runx3tm3Yg/Runx3tm3Yg
Tg(Scx-GFP)1Stzr/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation (0 available); any Runx3 mutation (27 available)
Tg(Scx-GFP)1Stzr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:243559 )
• do not display scoliosis at 3 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory