Phenotypes associated with this allele

• Allele Symbol: Runx3^tm3.1Yg
• Allele Name: targeted mutation 3.1, Yoram Groner
• Allele ID: MGI:5689489
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Runx3^tm3.1Yg/Runx3^tm3.1Yg	Not Specified	MGI:5689492

Genotype
MGI:5689492

hm1

• Allelic Composition: Runx3^tm3.1Yg/Runx3^tm3.1Yg
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:224290 )

decreased body height ( J:224290 )

• short stature

behavior/neurological

abnormal behavior ( J:224898 )

• mice exhibit all phenotypic features seen in Runx3^tm1Yg mice

ataxia ( J:224898 )

• congenital ataxia

limbs/digits/tail

short femur ( J:224290 )

digestive/alimentary system

abnormal digestive system physiology ( J:224898 )

• mice exhibit all phenotypic features seen in Runx3^tm1Yg mice

intestinal inflammation ( J:224898 )

• mice spontaneously develop inflammatory bowel disease

hematopoietic system

absent Langerhans cell ( J:224898 )

• lack of skin Langerhans cells

skeleton

short femur ( J:224290 )

decreased bone mineral content ( J:224290 )

decreased bone mineral density ( J:224290 )

• osteopenia

decreased compact bone area ( J:224290 )

• reduction in cortical area

immune system

absent Langerhans cell ( J:224898 )

• lack of skin Langerhans cells

abnormal immune system physiology ( J:224898 )

• mice exhibit all phenotypic features seen in Runx3^tm1Yg mice

intestinal inflammation ( J:224898 )

• mice spontaneously develop inflammatory bowel disease