Phenotypes associated with this allele

• Allele Symbol: Scml2^em2Shnk
• Allele Name: endonuclease-mediated mutation 2, Satoshi H Namekawa
• Allele ID: MGI:5690097
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scml2^em2Shnk/Scml2^em2Shnk	C57BL/6J-Scml2^em2Shnk	MGI:5690106

Genotype
MGI:5690106

hm1

• Allelic Composition: Scml2^em2Shnk/Scml2^em2Shnk
• Genetic Background: C57BL/6J-Scml2^em2Shnk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:225041 )

♂ • spermatozoa are rarely seen in the epididymis

multinucleated giant male germ cells ( J:225041 )

♂ • polynucleated male germ cells

increased male germ cell apoptosis ( J:225041 )

♂ • progressive apoptosis during differentiation in spermatogenesis

♂ • massive loss of differentiated male germ cells

small testis ( J:225041 )

♂

abnormal spermiogenesis ( J:225041 )

♂ • elongated spermatids fail to condense

♂ • however, the number of undifferentiated spermatogonia is normal

male infertility ( J:225041 )

♂

cellular

azoospermia ( J:225041 )

♂ • spermatozoa are rarely seen in the epididymis

multinucleated giant male germ cells ( J:225041 )

♂ • polynucleated male germ cells

increased male germ cell apoptosis ( J:225041 )

♂ • progressive apoptosis during differentiation in spermatogenesis

♂ • massive loss of differentiated male germ cells

endocrine/exocrine glands

small testis ( J:225041 )

♂