Phenotypes associated with this allele

• Allele Symbol: Nek7^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5690178
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nek7^M1Btlr/Nek7^M1Btlr	C57BL/6J-Nek7^M1Btlr	MGI:5698501
ht2	Nek7^M1Btlr/Nek7^+	C57BL/6J-Nek7^M1Btlr	MGI:5698502

Genotype
MGI:5698501

hm1

• Allelic Composition: Nek7^M1Btlr/Nek7^M1Btlr
• Genetic Background: C57BL/6J-Nek7^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

infertility ( J:226677 )

immune system

immune system phenotype ( J:226677 )

N • mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations and differentiation and proliferation of bone marrow hematopoietic stem cells and myeloid progenitor cells

abnormal macrophage physiology ( J:226677 )

• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage

• cyclic AMP levels are increased in Cuties macrophages compared to wild-type macrophages after LPS-priming and nigericin stimulation compared with wild-type cells

• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal

decreased interleukin-1 beta secretion ( J:226677 )

• from ATP- or alum-stimulated LPS-primed macrophages, bone marrow-derived macrophages and bone marrow-derived dendritic cells

• from Escherichia coli- or Citrobacter rodentium-infected macrophages

• however, response to flagellin or poly(dA:dT) is normal

decreased interleukin-18 secretion ( J:226677 )

• from nigericin, ATP or alum-stimulated LPS-primed macrophage

• from Escherichia coli- or Citrobacter rodentium-infected macrophages

• however, response to flagellin or poly(dA:dT) is normal

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:226677 )

• mice treated with recombinant human myelin oligodendrocyte glycoprotein exhibit reduced disease severity, reduced recruitment of lymphocytes, monocyte-microglia and natural killer cells to the spinal cord compared with wild-type mice

decreased inflammatory response ( J:226677 )

• monosodium urate crystal-treated mice exhibit impaired recruitment of total cells, neutrophils and F4/80+ monocytes-macrophages to the peritoneal cavity compared with wild-type mice

growth/size/body

decreased body weight ( J:226677 )

• at 2 months

• however, weight is normal at birth

behavior/neurological

abnormal gait ( J:226677 )

paresis ( J:226677 )

• slight

hematopoietic system

hematopoietic system phenotype ( J:226677 )

N • mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations and differentiation and proliferation of bone marrow hematopoietic stem cells and myeloid progenitor cells

abnormal macrophage physiology ( J:226677 )

• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage

• cyclic AMP levels are increased in Cuties macrophages compared to wild-type macrophages after LPS-priming and nigericin stimulation compared with wild-type cells

• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal

Genotype
MGI:5698502

ht2

• Allelic Composition: Nek7^M1Btlr/Nek7⁺
• Genetic Background: C57BL/6J-Nek7^M1Btlr

immune system

immune system phenotype ( J:226677 )

N • mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations

abnormal macrophage physiology ( J:226677 )

• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage

• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal

decreased interleukin-1 beta secretion ( J:226677 )

• from ATP- or alum-stimulated LPS-primed macrophages, bone marrow-derived macrophages and bone marrow-derived dendritic cells

• from Escherichia coli- or Citrobacter rodentium-infected macrophages

• however, response to flagellin or poly(dA:dT) is normal

decreased interleukin-18 secretion ( J:226677 )

• from nigericin, ATP or alum-stimulated LPS-primed macrophage

• from Escherichia coli- or Citrobacter rodentium-infected macrophages

• however, response to flagellin or poly(dA:dT) is normal

decreased inflammatory response ( J:226677 )

• monosodium urate crystal-treated mice exhibit impaired recruitment of total cells and neutrophils to the peritoneal cavity compared with wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:226677 )

N • mice exhibit normal macrophages, neutrophils, and other major lymphocyte populations

abnormal macrophage physiology ( J:226677 )

• decreased pyroptosis of nigericin, ATP or alum-stimulated LPS-primed macrophage

• however, pyroptosis response to flagellin, poly(dA:dT) or Escherichia coli- or Citrobacter rodentium-infected is normal