Phenotypes associated with this allele

• Allele Symbol: Rtn3^tm1Yanr
• Allele Name: targeted mutation 1, Riqiang Yan
• Allele ID: MGI:5691761
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtn3^tm1Yanr/Rtn3^tm1Yanr	involves: 129S6/SvEvTac * C57BL/6	MGI:7736591
cx2	Rtn3^tm1Yanr/Rtn3^tm1Yanr Tg(APPswe,PSEN1dE9)85Dbo/0	involves: 129S6/SvEvTac * C3H * C57BL/6	MGI:7736593

Genotype
MGI:7736591

hm1

• Allelic Composition: Rtn3^tm1Yanr/Rtn3^tm1Yanr
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine microalbumin level ( J:326034 )

• at 8 and 13 months of age but not at 2 months of age

abnormal kidney morphology ( J:326034 )

• hyalinosis at 13 months of age

increased renal glomerulus basement membrane thickness ( J:326034 )

• irregular thickening at 13 months of age

abnormal renal glomerulus morphology ( J:326034 )

• collagen aggregation in the glomerulus

glomerulosclerosis ( J:326034 )

• overt glomerulosclerosis at 8 months of age

• glomerulosclerosis is more severe following unilateral ureteral obstruction

abnormal kidney interstitium morphology ( J:326034 )

• collagen aggregation in the tubulointerstitium

abnormal renal tubule morphology ( J:326034 )

• mitochondria are disrupted

renal fibrosis ( J:326034 )

• at 8 and 13 months of age

• progresses with age

• fibrosis is more severe following unilateral ureteral obstruction

homeostasis/metabolism

increased circulating creatinine level ( J:326034 )

• at 8 and 13 months of age but not at 2 months of age

increased blood urea nitrogen level ( J:326034 )

• at 8 and 13 months of age but not at 2 months of age

increased urine microalbumin level ( J:326034 )

• at 8 and 13 months of age but not at 2 months of age

growth/size/body

growth/size/body region phenotype ( J:217161 )

N • no obvious growth defects

cellular

cellular phenotype ( J:217161 )

N • no obvious growth defects and no ER morphological abnormalities in cells or neurons

abnormal mitochondrial morphology ( J:326034 )

• disrupted in renal tubules

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic kidney disease		DOID:784		J:326034

Genotype
MGI:7736593

cx2

• Allelic Composition: Rtn3^tm1Yanr/Rtn3^tm1Yanr; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

nervous system

amyloid beta deposits ( J:217161 )

♀ • increased size of amyloid plaques compared to mice carrying the transgene and wild-type for Rtn3

homeostasis/metabolism

amyloid beta deposits ( J:217161 )

♀ • increased size of amyloid plaques compared to mice carrying the transgene and wild-type for Rtn3