Phenotypes associated with this allele

• Allele Symbol: Ldoc1^tm1.1Tmki
• Allele Name: targeted mutation 1, Tomoko Kaneko-Ishino
• Allele ID: MGI:5691781
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ldoc1^tm1.1Tmki/Ldoc1^tm1.1Tmki	B6.129S-Ldoc1^tm1.1Tmki	MGI:6259416
ot2	Ldoc1^tm1.1Tmki/Y	B6.129S-Ldoc1^tm1.1Tmki	MGI:6259417

Genotype
MGI:6259416

hm1

• Allelic Composition: Ldoc1^tm1.1Tmki/Ldoc1^tm1.1Tmki
• Genetic Background: B6.129S-Ldoc1^tm1.1Tmki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta morphology ( J:217586 )

♂ • irregular boundary between the spongiotrophoblast and labyrinth layers at E12.5

abnormal trophoblast layer morphology ( J:217586 )

♂ • trophoblast layers appear thicker at E10.5

abnormal trophoblast giant cell morphology ( J:217586 )

♂ • expression analysis indicates abnormalities in trophoblast giant cells

abnormal spongiotrophoblast layer morphology ( J:217586 )

♂ • decreased spongiotrophoblast to glycogen trophoblast cell ratio at E12.5 - E15.5

decreased spongiotrophoblast cell number ( J:217586 )

♂ • decreased number of spongiotrophoblast cells but normal number of glycogen trophoblast cells

Genotype
MGI:6259417

ot2

• Allelic Composition: Ldoc1^tm1.1Tmki/Y
• Genetic Background: B6.129S-Ldoc1^tm1.1Tmki

reproductive system

delayed parturition ( J:217586 )

♀ • about 49% of females display delayed parturition by ~1-4 days

embryo

abnormal placenta morphology ( J:217586 )

♀ • irregular boundary between the spongiotrophoblast and labyrinth layers at E12.5

abnormal trophoblast layer morphology ( J:217586 )

♀ • trophoblast layers appear thicker at E10.5

abnormal trophoblast giant cell morphology ( J:217586 )

♀ • expression analysis indicates abnormalities in trophoblast giant cells

abnormal spongiotrophoblast layer morphology ( J:217586 )

♀ • decreased spongiotrophoblast to glycogen trophoblast cell ratio at E12.5 - E15.5

decreased spongiotrophoblast cell number ( J:217586 )

♀ • decreased number of spongiotrophoblast cells but normal number of glycogen trophoblast cells

behavior/neurological

abnormal maternal nurturing ( J:217586 )

♀ • decrease in the average number of weaned pups, 1.7 compared to 5.8 pups per litter for controls

♀ • however, when raised by foster mothers litter size is similar to controls

homeostasis/metabolism

abnormal progesterone level ( J:217586 )

♀ • placental progesterone levels on d10.5 and d11.5 are about double that of controls but slightly lower on d9.5 suggesting delay in production

increased circulating progesterone level ( J:217586 )

♀ • increased serum P4 levels at day 18.5 of pregnancy in ~50% of females